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Two pore segment channel 2
Symbols TPCN2 ; SHEP10; TPC2
External IDs OMIM612163 MGI2385297 HomoloGene16375 IUPHAR: 393 GeneCards: TPCN2 Gene
Species Human Mouse
Entrez 219931 233979
Ensembl ENSG00000162341 ENSMUSG00000048677
UniProt Q8NHX9 Q8BWC0
RefSeq (mRNA) NM_139075 NM_146206
RefSeq (protein) NP_620714 NP_666318
Location (UCSC) Chr 11:
69.05 – 69.09 Mb
Chr 7:
145.25 – 145.28 Mb
PubMed search [1] [2]

Two pore segment channel 2 (TPC2) is a human protein encoded by the TPCN2 is a protein which in humans is encoded by the TPCN2 gene.[1] TPC2 is an ion channel, however, in contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments (S1 to S6), TPCN1 only contains two domain (each containing segments S1 to S6).[2]

See also[edit]


  1. ^ "Entrez Gene: two pore segment channel 2". 
  2. ^ Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. 

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