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Tropomyosin 2 (beta)
Symbols TPM2 ; AMCD1; DA1; DA2B; HEL-S-273; NEM4; TMSB
External IDs OMIM190990 MGI98810 HomoloGene134045 GeneCards: TPM2 Gene
RNA expression pattern
PBB GE TPM2 204083 s at tn.png
PBB GE TPM2 212654 at tn.png
More reference expression data
Species Human Mouse
Entrez 7169 22004
Ensembl ENSG00000198467 ENSMUSG00000028464
UniProt P07951 P58774
RefSeq (mRNA) NM_001145822 NM_001277875
RefSeq (protein) NP_001288155 NP_001264804
Location (UCSC) Chr 9:
35.68 – 35.69 Mb
Chr 4:
43.51 – 43.52 Mb
PubMed search [1] [2]

Tropomyosin beta chain is a protein that in humans is encoded by the TPM2 gene.[1][2]


TPM2 has been shown to interact with RRAD,[3] PDLIM7[4] and TPM1.[5]


  1. ^ Hunt CC, Eyre HJ, Akkari PA, Meredith C, Dorosz SM, Wilton SD, Callen DF, Laing NG, Baker E (Aug 1995). "Assignment of the human beta tropomyosin gene (TPM2) to band 9p13 by fluorescence in situ hybridisation". Cytogenet Cell Genet 71 (1): 94–95. doi:10.1159/000134070. PMID 7606936. 
  2. ^ "Entrez Gene: TPM2 tropomyosin 2 (beta)". 
  3. ^ Zhu, J; Bilan P J; Moyers J S; Antonetti D A; Kahn C R (Jan 1996). "Rad, a novel Ras-related GTPase, interacts with skeletal muscle beta-tropomyosin". J. Biol. Chem. (UNITED STATES) 271 (2): 768–773. doi:10.1074/jbc.271.2.768. ISSN 0021-9258. PMID 8557685. 
  4. ^ Guy, P M; Kenny D A; Gill G N (Jun 1999). "The PDZ domain of the LIM protein enigma binds to beta-tropomyosin". Mol. Biol. Cell (UNITED STATES) 10 (6): 1973–84. doi:10.1091/mbc.10.6.1973. ISSN 1059-1524. PMC 25398. PMID 10359609. 
  5. ^ Brown, H R; Schachat F H (Apr 1985). "Renaturation of skeletal muscle tropomyosin: implications for in vivo assembly". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 82 (8): 2359–2363. doi:10.1073/pnas.82.8.2359. ISSN 0027-8424. PMC 397557. PMID 3857586. 

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