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Aliases TPPP, TPPP/p25, TPPP1, p24, p25, p25alpha, tubulin polymerization promoting protein
External IDs MGI: 1920198 HomoloGene: 21389 GeneCards: TPPP
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 0.66 – 0.69 Mb Chr 13: 74.01 – 74.04 Mb
PubMed search [1] [2]
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Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene.[3][4][5][6][7]

This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients.[8]

This has also been linked to Parkinson's and Alsheimers Disease[9][10]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T, Saito T (Apr 1999). "A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3". J Hum Genet. 44 (2): 121–2. doi:10.1007/s100380050122. PMID 10083737. 
  4. ^ Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J (Jul 2002). "Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations". Biochemistry. 41 (27): 8657–64. doi:10.1021/bi020140g. PMID 12093283. 
  5. ^ Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, Hojrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH (Feb 2005). "p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies". J Biol Chem. 280 (7): 5703–15. doi:10.1074/jbc.M410409200. PMID 15590652. 
  6. ^ Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J (Nov 2006). "Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions". Biochemistry. 45 (46): 13818–26. doi:10.1021/bi061305e. PMID 17105200. 
  7. ^ "Entrez Gene: TPPP brain-specific protein p25 alpha". 
  8. ^ Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J (May 2011). "A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis". Biochem. Biophys. Res. Commun. 409 (1): 137–41. doi:10.1016/j.bbrc.2011.04.130. PMID 21565174. 
  9. ^ Kovács, Gábor G.; László, Lajos; Kovács, János; Jensen, Poul Henning; Lindersson, Evo; Botond, Gergő; Molnár, Tamás; Perczel, András; Hudecz, Ferenc (2004-11-01). "Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies". Neurobiology of Disease. 17 (2): 155–162. doi:10.1016/j.nbd.2004.06.006. 
  10. ^ Kovács, Gábor G.; Gelpi, Ellen; Lehotzky, Attila; Höftberger, Romana; Erdei, Anna; Budka, Herbert; Ovádi, Judit (2006-11-23). "The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases". Acta Neuropathologica. 113 (2): 153–161. doi:10.1007/s00401-006-0167-4. ISSN 0001-6322. PMID 17123092. 

Further reading[edit]