TRAF interacting protein

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesTRAIP, RNF206, TRIP, SCKL9, TRAF interacting protein
External IDsOMIM: 605958 MGI: 1096377 HomoloGene: 31343 GeneCards: TRAIP
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for TRAIP
Genomic location for TRAIP
Band3p21.31Start49,828,601 bp[1]
End49,856,574 bp[1]
RNA expression pattern
PBB GE TRAIP 205598 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 3: 49.83 – 49.86 MbChr 9: 107.95 – 107.97 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.[5][6]

This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.[6]


TRAF interacting protein has been shown to interact with FLII,[7] TRAF1[5] and TRAF2.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183763 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032586 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Lee SY, Lee SY, Choi Y (April 1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation". The Journal of Experimental Medicine. 185 (7): 1275–85. doi:10.1084/jem.185.7.1275. PMC 2196258. PMID 9104814.
  6. ^ a b "Entrez Gene: TRAIP TRAF interacting protein".
  7. ^ Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (August 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Research. 26 (15): 3460–7. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.

Further reading[edit]

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