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TNF receptor-associated protein 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TRAP1 ; HSP 75; HSP75; HSP90L; TRAP-1
External IDs OMIM606219 MGI1915265 HomoloGene9457 ChEMBL: 1075132 GeneCards: TRAP1 Gene
RNA expression pattern
PBB GE TRAP1 201391 at tn.png
More reference expression data
Species Human Mouse
Entrez 10131 68015
Ensembl ENSG00000126602 ENSMUSG00000005981
UniProt Q12931 Q9CQN1
RefSeq (mRNA) NM_001272049 NM_026508
RefSeq (protein) NP_001258978 NP_080784
Location (UCSC) Chr 16:
3.65 – 3.72 Mb
Chr 16:
4.04 – 4.08 Mb
PubMed search [1] [2]

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.[1][2][3]


TRAP1 has been shown to interact with EXT2,[4] EXT1[4] and Retinoblastoma protein.[5]


  1. ^ Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties". J Biol Chem 275 (5): 3305–12. doi:10.1074/jbc.275.5.3305. PMID 10652318. 
  2. ^ Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB (March 1995). "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor". J Biol Chem 270 (8): 3574–81. doi:10.1074/jbc.270.8.3574. PMID 7876093. 
  3. ^ "Entrez Gene: TRAP1 TNF receptor-associated protein 1". 
  4. ^ a b Simmons, A D; Musy M M; Lopes C S; Hwang L Y; Yang Y P; Lovett M (November 1999). "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses". Hum. Mol. Genet. (ENGLAND) 8 (12): 2155–64. doi:10.1093/hmg/8.12.2155. ISSN 0964-6906. PMID 10545594. 
  5. ^ Chen, C F; Chen Y; Dai K; Chen P L; Riley D J; Lee W H (September 1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock". Mol. Cell. Biol. (UNITED STATES) 16 (9): 4691–9. ISSN 0270-7306. PMC 231469. PMID 8756626. 

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