TRDMT1

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TRDMT1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TRDMT1, DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1, tRNA aspartic acid methyltransferase 1
External IDs MGI: 1274787 HomoloGene: 3249 GeneCards: TRDMT1
RNA expression pattern
PBB GE TRDMT1 206308 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010067

RefSeq (protein)

NP_034197.3
NP_034197

Location (UCSC) Chr 10: 17.14 – 17.2 Mb Chr 2: 13.51 – 13.54 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

tRNA (cytosine-5-)-methyltransferase is an enzyme that in humans is encoded by the TRDMT1 gene.[3][4][5][6]

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.[6]

It has been shown that human DNMT2 does not methylate DNA but instead methylates cytosine 38 in the anticodon loop of aspartic acid transfer RNA (tRNA(Asp)).[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yoder JA, Bestor TH (Mar 1998). "A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast". Hum Mol Genet. 7 (2): 279–84. doi:10.1093/hmg/7.2.279. PMID 9425235. 
  4. ^ Vilain A, Apiou F, Dutrillaux B, Malfoy B (Nov 1998). "Assignment of candidate DNA methyltransferase gene (DNMT2) to human chromosome band 10p15.1 by in situ hybridization". Cytogenet Cell Genet. 82 (1–2): 120. doi:10.1159/000015083. PMID 9763678. 
  5. ^ Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH (Jan 2006). "Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2". Science. 311 (5759): 395–8. doi:10.1126/science.1120976. PMID 16424344. 
  6. ^ a b "Entrez Gene: TRDMT1 tRNA aspartic acid methyltransferase 1". 
  7. ^ Goll MG, Kirpekar F, Maggert KA, et al. (2006). "Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2". Science. 311 (5759): 395–8. doi:10.1126/science.1120976. PMID 16424344. 

Further reading[edit]