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T cell receptor gamma locus
Symbols TRG ; TCRG; TRG@
External IDs OMIM186970 GeneCards: TRG Gene
Species Human Mouse
Entrez 6965 n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search [1] n/a

T-cell receptor gamma chain C region PT-gamma-1/2 is a protein that in humans is encoded by the TRG@ gene.[1][2][3]

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the gamma locus are known to be incapable of encoding a protein and are considered pseudogenes. Somatic rearrangement of the gamma locus has been observed in T cells derived from patients with T cell leukemia and ataxia telangiectasia.[3]


  1. ^ Lefranc MP, Chuchana P, Dariavach P, Nguyen C, Huck S, Brockly F, Jordan B, Lefranc G (Aug 1989). "Molecular mapping of the human T cell receptor gamma (TRG) genes and linkage of the variable and constant regions". Eur J Immunol 19 (6): 989–94. doi:10.1002/eji.1830190606. PMID 2526744. 
  2. ^ Littman DR, Newton M, Crommie D, Ang SL, Seidman JG, Gettner SN, Weiss A (Apr 1987). "Characterization of an expressed CD3-associated Ti gamma-chain reveals C gamma domain polymorphism". Nature 326 (6108): 85–8. doi:10.1038/326085a0. PMID 3102973. 
  3. ^ a b "Entrez Gene: TRG@ T cell receptor gamma locus". 

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