TRIM23

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TRIM23
Identifiers
Aliases TRIM23, ARD1, ARFD1, RNF46, tripartite motif containing 23
External IDs MGI: 1933161 HomoloGene: 1251 GeneCards: TRIM23
RNA expression pattern
PBB GE TRIM23 210994 x at fs.png

PBB GE TRIM23 204732 s at fs.png

PBB GE TRIM23 210995 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001656
NM_033227
NM_033228

NM_030731

RefSeq (protein)

NP_001647
NP_150230
NP_150231

NP_109656.1
NP_109656

Location (UCSC) Chr 5: 65.59 – 65.63 Mb Chr 13: 104.18 – 104.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

GTP-binding protein ARD-1 is a protein that in humans is encoded by the TRIM23 gene.[3][4]

Function[edit]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phospholipase D activation. Three alternatively spliced transcript variants for this gene have been described.[4]

Interactions[edit]

TRIM23 has been shown to interact with TRIM31,[5] TRIM29[5] and PSCD1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (Apr 1993). "ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain". The Journal of Biological Chemistry. 268 (12): 8801–7. PMID 8473324. 
  4. ^ a b "Entrez Gene: TRIM23 tripartite motif-containing 23". 
  5. ^ a b Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". The EMBO Journal. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245Freely accessible. PMID 11331580. 
  6. ^ Vitale N, Pacheco-Rodriguez G, Ferrans VJ, Riemenschneider W, Moss J, Vaughan M (Jul 2000). "Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1)". The Journal of Biological Chemistry. 275 (28): 21331–9. doi:10.1074/jbc.M909642199. PMID 10748148. 

Further reading[edit]