TRIM68

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TRIM68
Identifiers
AliasesTRIM68, GC109, RNF137, SS-56, SS56, tripartite motif containing 68
External IDsMGI: 2142077 HomoloGene: 9991 GeneCards: TRIM68
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for TRIM68
Genomic location for TRIM68
Band11p15.4Start4,598,672 bp[1]
End4,608,231 bp[1]
RNA expression pattern
PBB GE TRIM68 219405 at fs.png

PBB GE TRIM68 gnf1h05427 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018073
NM_001304496

NM_198012
NM_001307998

RefSeq (protein)

NP_001291425
NP_060543

n/a

Location (UCSC)Chr 11: 4.6 – 4.61 MbChr 7: 102.68 – 102.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif-containing protein 68 is a protein that in humans is encoded by the TRIM68 gene.[5][6]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.[6]

Interactions[edit]

TRIM68 has been shown to interact with Androgen receptor.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167333 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073968 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Chang GT, Steenbeek M, Schippers E, Blok LJ, van Weerden WM, van Alewijk DC, et al. (November 2001). "A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells". European Journal of Cancer. 37 (16): 2129–34. doi:10.1016/S0959-8049(01)00259-3. PMID 11597395.
  6. ^ a b "Entrez Gene: TRIM68 tripartite motif-containing 68".
  7. ^ Miyajima N, Maruyama S, Bohgaki M, Kano S, Shigemura M, Shinohara N, et al. (May 2008). "TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells". Cancer Research. 68 (9): 3486–94. doi:10.1158/0008-5472.CAN-07-6059. PMID 18451177.

Further reading[edit]