TRIO (gene)

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Trio Rho guanine nucleotide exchange factor
Protein TRIO PDB 1nty.png
PDB rendering based on 1nty.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TRIO ; ARHGEF23; tgat
External IDs OMIM601893 MGI1927230 HomoloGene20847 GeneCards: TRIO Gene
EC number
RNA expression pattern
PBB GE TRIO 209012 at tn.png
PBB GE TRIO 208178 x at tn.png
PBB GE TRIO 209010 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7204 223435
Ensembl ENSG00000038382 ENSMUSG00000022263
UniProt O75962 Q0KL02
RefSeq (mRNA) NM_007118 NM_001081302
RefSeq (protein) NP_009049 NP_001074771
Location (UCSC) Chr 5:
14.14 – 14.53 Mb
Chr 15:
27.73 – 28.03 Mb
PubMed search [1] [2]

Triple functional domain protein is a protein that in humans is encoded by the TRIO gene.[1][2]


TRIO (gene) has been shown to interact with Filamin[3] and RHOA.[4]


  1. ^ Debant A, Serra-Pagès C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (May 1996). "The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains". Proceedings of the National Academy of Sciences of the United States of America 93 (11): 5466–71. doi:10.1073/pnas.93.11.5466. PMC 39269. PMID 8643598. 
  2. ^ "Entrez Gene: TRIO triple functional domain (PTPRF interacting)". 
  3. ^ Bellanger JM, Astier C, Sardet C, Ohta Y, Stossel TP, Debant A (Dec 2000). "The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin". Nature Cell Biology 2 (12): 888–92. doi:10.1038/35046533. PMID 11146652. 
  4. ^ Medley QG, Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien SP, Streuli M (Nov 2000). "The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain". The Journal of Biological Chemistry 275 (46): 36116–23. doi:10.1074/jbc.M003775200. PMID 10948190. 

Further reading[edit]