TRIO (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein TRIO PDB 1nty.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TRIO, ARHGEF23, tgat, trio Rho guanine nucleotide exchange factor
External IDs MGI: 1927230 HomoloGene: 20847 GeneCards: 7204
Genetically Related Diseases
Disease Name References
RNA expression pattern
PBB GE TRIO 208178 x at tn.png

PBB GE TRIO 209010 s at tn.png

PBB GE TRIO 209012 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 14.14 – 14.53 Mb Chr 15: 27.73 – 28.03 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Triple functional domain protein is a protein that in humans is encoded by the TRIO gene.[4][5]


TRIO (gene) has been shown to interact with Filamin[6] and RHOA.[7]


  1. ^ "". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Debant A, Serra-Pagès C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (May 1996). "The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5466–71. doi:10.1073/pnas.93.11.5466. PMC 39269free to read. PMID 8643598. 
  5. ^ "Entrez Gene: TRIO triple functional domain (PTPRF interacting)". 
  6. ^ Bellanger JM, Astier C, Sardet C, Ohta Y, Stossel TP, Debant A (Dec 2000). "The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin". Nature Cell Biology. 2 (12): 888–92. doi:10.1038/35046533. PMID 11146652. 
  7. ^ Medley QG, Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien SP, Streuli M (Nov 2000). "The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain". The Journal of Biological Chemistry. 275 (46): 36116–23. doi:10.1074/jbc.M003775200. PMID 10948190. 

Further reading[edit]