TRIO (gene)

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Protein TRIO PDB 1nty.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesTRIO, ARHGEF23, tgat, trio Rho guanine nucleotide exchange factor, MEBAS, MRD44
External IDsOMIM: 601893 MGI: 1927230 HomoloGene: 20847 GeneCards: TRIO
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for TRIO
Genomic location for TRIO
Band5p15.2Start14,143,342 bp[1]
End14,532,128 bp[1]
RNA expression pattern
PBB GE TRIO 209012 at fs.png

PBB GE TRIO 209010 s at fs.png

PBB GE TRIO 208178 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 5: 14.14 – 14.53 MbChr 15: 27.73 – 28.03 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Triple functional domain protein is a protein that in humans is encoded by the TRIO gene.[5][6]


TRIO (gene) has been shown to interact with Filamin[7] and RHOA.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000038382 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022263 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Debant A, Serra-Pagès C, Seipel K, O'Brien S, Tang M, Park SH, Streuli M (May 1996). "The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5466–71. doi:10.1073/pnas.93.11.5466. PMC 39269. PMID 8643598.
  6. ^ "Entrez Gene: TRIO triple functional domain (PTPRF interacting)".
  7. ^ Bellanger JM, Astier C, Sardet C, Ohta Y, Stossel TP, Debant A (Dec 2000). "The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin". Nature Cell Biology. 2 (12): 888–92. doi:10.1038/35046533. PMID 11146652.
  8. ^ Medley QG, Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien SP, Streuli M (Nov 2000). "The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain". The Journal of Biological Chemistry. 275 (46): 36116–23. doi:10.1074/jbc.M003775200. PMID 10948190.

Further reading[edit]