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Protein TRIP10 PDB 2ct4.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TRIP10, CIP4, HSTP, STOT, STP, TRIP-10, thyroid hormone receptor interactor 10
External IDs MGI: 2146901 HomoloGene: 99728 GeneCards: TRIP10
RNA expression pattern
PBB GE TRIP10 202734 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC) Chr 19: 6.74 – 6.75 Mb Chr 17: 57.25 – 57.26 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Cdc42-interacting protein 4 is a protein that in humans is encoded by the TRIP10 gene.[3][4][5][6]


TRIP10 has been shown to interact with STAT3,[7] Wiskott-Aldrich syndrome protein,[8] Huntingtin,[9] CDC42,[4][8] AKAP9[10] and RHOQ.[11]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (July 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol Endocrinol. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974. 
  4. ^ a b Aspenstrom P (August 1997). "A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton". Curr Biol. 7 (7): 479–87. doi:10.1016/S0960-9822(06)00219-3. PMID 9210375. 
  5. ^ Tsuji E, Tsuji Y (April 2001). "Molecular cloning and chromosomal localization of human salt-tolerant protein". Genetica. 108 (3): 259–62. doi:10.1023/A:1004132919896. PMID 11294612. 
  6. ^ "Entrez Gene: TRIP10 thyroid hormone receptor interactor 10". 
  7. ^ Chung, Young-Hwa; Cho Nam-hyuk; Garcia Maria Ines; Lee Sun-Hwa; Feng Pinghui; Jung Jae U (June 2004). "Activation of Stat3 transcription factor by Herpesvirus saimiri STP-A oncoprotein". J. Virol. United States. 78 (12): 6489–97. doi:10.1128/JVI.78.12.6489-6497.2004. ISSN 0022-538X. PMC 416526Freely accessible. PMID 15163742. 
  8. ^ a b Tian, L; Nelson D L; Stewart D M (March 2000). "Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules". J. Biol. Chem. UNITED STATES. 275 (11): 7854–61. doi:10.1074/jbc.275.11.7854. ISSN 0021-9258. PMID 10713100. 
  9. ^ Holbert, Sébastien; Dedeoglu Alpaslan; Humbert Sandrine; Saudou Frédéric; Ferrante Robert J; Néri Christian (March 2003). "Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease". Proc. Natl. Acad. Sci. U.S.A. United States. 100 (5): 2712–7. doi:10.1073/pnas.0437967100. ISSN 0027-8424. PMC 151406Freely accessible. PMID 12604778. 
  10. ^ Larocca, M Cecilia; Shanks Ryan A; Tian Lan; Nelson David L; Stewart Donn M; Goldenring James R (June 2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell. United States. 15 (6): 2771–81. doi:10.1091/mbc.E03-10-0757. ISSN 1059-1524. PMC 420101Freely accessible. PMID 15047863. 
  11. ^ Chang, Louise; Adams Rachael D; Saltiel Alan R (October 2002). "The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes". Proc. Natl. Acad. Sci. U.S.A. United States. 99 (20): 12835–40. doi:10.1073/pnas.202495599. ISSN 0027-8424. PMC 130546Freely accessible. PMID 12242347. 

Further reading[edit]