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Protein TRIP6 PDB 1x61.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TRIP6, OIP-1, OIP1, TRIP-6, TRIP6i2, ZRP-1, thyroid hormone receptor interactor 6
External IDs MGI: 1343458 HomoloGene: 37757 GeneCards: TRIP6
RNA expression pattern
PBB GE TRIP6 209129 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 100.87 – 100.87 Mb Chr 5: 137.31 – 137.31 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.[3][4][5]


This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[5]


TRIP6 has been shown to interact with LPAR2,[6] BCAR1[6][7] and HOXA9.[8]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yi J, Beckerle MC (Apr 1998). "The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis". Genomics. 49 (2): 314–6. doi:10.1006/geno.1998.5248. PMID 9598321. 
  4. ^ Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (Feb 1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Molecular Endocrinology. 9 (2): 243–54. doi:10.1210/me.9.2.243. PMID 7776974. 
  5. ^ a b "Entrez Gene: TRIP6 thyroid hormone receptor interactor 6". 
  6. ^ a b Xu J, Lai YJ, Lin WC, Lin FT (Mar 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". The Journal of Biological Chemistry. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMID 14688263. 
  7. ^ Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC (Mar 2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". The Journal of Biological Chemistry. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456. 
  8. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]