TRNT1

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TRNT1
Protein TRNT1 PDB 1ou5.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRNT1, CCA1, MtCCA, CGI-47, SIFD, tRNA nucleotidyl transferase 1, RPEM
External IDsMGI: 1917297 HomoloGene: 9333 GeneCards: TRNT1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for TRNT1
Genomic location for TRNT1
Band3p26.2Start3,126,916 bp[1]
End3,150,879 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001302946
NM_016000
NM_182916

NM_001242358
NM_001242360
NM_027296

RefSeq (protein)

NP_001289875
NP_886552

NP_001229287
NP_001229289
NP_081572

Location (UCSC)Chr 3: 3.13 – 3.15 MbChr 6: 106.77 – 106.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA-nucleotidyltransferase 1, is an enzyme that in humans is encoded by the TRNT1 gene.[5][6][7] This enzyme adds the nucleotide sequence CCA to the 3' end of tRNA, using ATP and CTP as substrates. The sequence creates the binding site for an amino acid.[8]


References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072756 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000013736 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876Freely accessible. PMID 10810093. 
  6. ^ Nagaike T, Suzuki T, Tomari Y, Takemoto-Hori C, Negayama F, Watanabe K, Ueda T (Oct 2001). "Identification and characterization of mammalian mitochondrial tRNA nucleotidyltransferases". J Biol Chem. 276 (43): 40041–9. doi:10.1074/jbc.M106202200. PMID 11504732. 
  7. ^ "Entrez Gene: TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1". 
  8. ^ Lizano E, Scheibe M, Rammelt C, Betat H, Mörl M (May 2008). "A comparative analysis of CCA-adding enzymes from human and E. coli: differences in CCA addition and tRNA 3'-end repair". Biochimie. 90 (5): 762–72. doi:10.1016/j.biochi.2007.12.007. PMID 18226598. 

Further reading[edit]