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Transient receptor potential cation channel, subfamily C, member 1
Symbols TRPC1 ; HTRP-1; TRP1
External IDs OMIM602343 MGI109528 HomoloGene2478 IUPHAR: 486 GeneCards: TRPC1 Gene
RNA expression pattern
PBB GE TRPC1 205803 s at tn.png
PBB GE TRPC1 205802 at tn.png
PBB GE TRPC1 211602 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7220 22063
Ensembl ENSG00000144935 ENSMUSG00000032839
UniProt P48995 Q61056
RefSeq (mRNA) NM_001251845 NM_011643
RefSeq (protein) NP_001238774 NP_035773
Location (UCSC) Chr 3:
142.72 – 142.81 Mb
Chr 9:
95.71 – 95.75 Mb
PubMed search [1] [2]

Transient receptor potential channel 1 (TRPC1) is a protein that in humans is encoded by the TRPC1 gene.[1][2]


TRPC1 is an ion channel located on the plasma membrane of numerous human and animal cell types. [3] It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the phospholipase C system. In HEK293 cells the unitary current-voltage relationship of endogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV.[4] The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5. [5][6] The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.[6]


TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the TRP channel in Drosophila. Together with TRPC3 they became the founding members of the TRPC ion channel family.[1][2]


TRPC1 has been shown to interact with HOMER3,[7] Polycystic kidney disease 2,[8] TRPC5,[9][10] TRPC3,[9][11] RHOA[12] and TRPC4.[9][10]

See also[edit]


  1. ^ a b Wes PD, Chevesich J, Jeromin A, Rosenberg C, Stetten G, Montell C (October 1995). "TRPC1, a human homolog of a Drosophila store-operated channel". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9652–6. doi:10.1073/pnas.92.21.9652. PMC 40860. PMID 7568191. 
  2. ^ a b Zhu X, Chu PB, Peyton M, Birnbaumer L (October 1995). "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene". FEBS Lett 373 (3): 193–8. doi:10.1016/0014-5793(95)01038-G. PMID 7589464. 
  3. ^ Xu, SZ; Beech, DJ (2001). "TrpC1 is a membrane-spanning subunit of store-operated Ca(2+) channels in native vascular smooth muscle cells". Circ Res. 88 (1): 84–7. doi:10.1161/01.res.88.1.84. PMID 11139478. 
  4. ^ Skopin A, Shalygin A, Vigont V, Zimina O, Glushankova L, Mozhayeva GN, Kaznacheyeva E. (2013) "TRPC1 protein forms only one type of native store-operated channels in HEK293 cells."
  5. ^ Fowler, MA; Sidiropoulou, K; Ozkan, ED; Phillips, CW; Cooper, DC (2007). "Corticolimbic Expression of TRPC4 and TRPC5 Channels in the Rodent Brain". PLoS ONE 2 (6): e573. doi:10.1371/journal.pone.0000573. 
  6. ^ a b Fowler, M, Varnell, A , Dietrich, A., Birnbaumer, L., & Cooper, DC. (2012) Deletion of the trpc1 gene and the effects on locomotor and conditioned place-preference responses to cocaine. Nature Precedings doi:10.1038/npre.2012.7153.1
  7. ^ Yuan, Joseph P; Kiselyov Kirill, Shin Dong Ming, Chen Jin, Shcheynikov Nikolay, Kang Shin H, Dehoff Marlin H, Schwarz Martin K, Seeburg Peter H, Muallem Shmuel, Worley Paul F (Sep 2003). "Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors". Cell (United States) 114 (6): 777–89. doi:10.1016/S0092-8674(03)00716-5. ISSN 0092-8674. PMID 14505576. 
  8. ^ Tsiokas, L; Arnould T; Zhu C; Kim E; Walz G; Sukhatme V P (Mar 1999). "Specific association of the gene product of PKD2 with the TRPC1 channel". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (7): 3934–9. doi:10.1073/pnas.96.7.3934. ISSN 0027-8424. PMC 22398. PMID 10097141. 
  9. ^ a b c Strübing, Carsten; Krapivinsky Grigory; Krapivinsky Luba; Clapham David E (Oct 2003). "Formation of novel TRPC channels by complex subunit interactions in embryonic brain". J. Biol. Chem. (United States) 278 (40): 39014–9. doi:10.1074/jbc.M306705200. ISSN 0021-9258. PMID 12857742. 
  10. ^ a b Hofmann, Thomas; Schaefer Michael; Schultz Günter; Gudermann Thomas (May 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (11): 7461–6. doi:10.1073/pnas.102596199. ISSN 0027-8424. PMC 124253. PMID 12032305. 
  11. ^ Xu, X Z; Li H S; Guggino W B; Montell C (Jun 1997). "Coassembly of TRP and TRPL produces a distinct store-operated conductance". Cell (UNITED STATES) 89 (7): 1155–64. doi:10.1016/S0092-8674(00)80302-5. ISSN 0092-8674. PMID 9215637. 
  12. ^ Mehta, Dolly; Ahmmed Gias U, Paria Biman C, Holinstat Michael, Voyno-Yasenetskaya Tatyana, Tiruppathi Chinnaswamy, Minshall Richard D, Malik Asrar B (Aug 2003). "RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability". J. Biol. Chem. (United States) 278 (35): 33492–500. doi:10.1074/jbc.M302401200. ISSN 0021-9258. PMID 12766172. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.