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Transient receptor potential cation channel, subfamily C, member 4 associated protein
Symbols TRPC4AP ; C20orf188; PPP1R158; TRRP4AP; TRUSS
External IDs OMIM608430 MGI1930751 HomoloGene9224 GeneCards: TRPC4AP Gene
RNA expression pattern
PBB GE TRPC4AP 212059 s at tn.png
More reference expression data
Species Human Mouse
Entrez 26133 56407
Ensembl ENSG00000100991 ENSMUSG00000038324
UniProt Q8TEL6 Q9JLV2
RefSeq (mRNA) NM_015638 NM_001163452
RefSeq (protein) NP_056453 NP_001156924
Location (UCSC) Chr 20:
35 – 35.09 Mb
Chr 2:
155.63 – 155.69 Mb
PubMed search [1] [2]

Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.

Model organisms[edit]

Model organisms have been used in the study of TRPC4AP function. A conditional knockout mouse line, called Trpc4aptm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty five tests were carried out on mutant mice and three significant abnormalities were observed.[4] Few homozygous mutant embryos were identified during gestation, and thus fewer than expected survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; females had an abnormal anagen phase of the hair cycle.[4]


TRPC4AP has been shown to interact with TNFRSF1A.[12][clarification needed]

See also[edit]

Further reading[edit]


  1. ^ "Dysmorphology data for Trpc4ap". Wellcome Trust Sanger Institute. 
  2. ^ "Salmonella infection data for Trpc4ap". Wellcome Trust Sanger Institute. 
  3. ^ "Citrobacter infection data for Trpc4ap". Wellcome Trust Sanger Institute. 
  4. ^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  5. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ^ "International Knockout Mouse Consortium". 
  7. ^ "Mouse Genome Informatics". 
  8. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  9. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  10. ^ Collins FS, Rossant J, Wurst W (2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  11. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 
  12. ^ Soond SM, Terry JL, Colbert JD, Riches DW (Nov 2003). "TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB". Mol. Cell. Biol. 23 (22): 8334–44. doi:10.1128/MCB.23.22.8334-8344.2003. PMC 262424. PMID 14585990.