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AliasesTRPC4AP, C20orf188, PPP1R158, TRRP4AP, TRUSS, transient receptor potential cation channel subfamily C member 4 associated protein
External IDsOMIM: 608430 MGI: 1930751 HomoloGene: 9224 GeneCards: TRPC4AP
Gene location (Human)
Chromosome 20 (human)
Chr.Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for TRPC4AP
Genomic location for TRPC4AP
Band20q11.22Start35,002,404 bp[1]
End35,092,807 bp[1]
RNA expression pattern
PBB GE TRPC4AP 212059 s at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 20: 35 – 35.09 MbChr 2: 155.63 – 155.69 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.

Model organisms[edit]

Model organisms have been used in the study of TRPC4AP function. A conditional knockout mouse line, called Trpc4aptm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[12][13][14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty five tests were carried out on mutant mice and three significant abnormalities were observed.[8] Few homozygous mutant embryos were identified during gestation, and thus fewer than expected survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; females had an abnormal anagen phase of the hair cycle.[8]


TRPC4AP has been shown to interact with TNFRSF1A.[16][clarification needed]

See also[edit]

Further reading[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100991 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038324 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Dysmorphology data for Trpc4ap". Wellcome Trust Sanger Institute.
  6. ^ "Salmonella infection data for Trpc4ap". Wellcome Trust Sanger Institute.
  7. ^ "Citrobacter infection data for Trpc4ap". Wellcome Trust Sanger Institute.
  8. ^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  9. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. ^ "International Knockout Mouse Consortium".
  11. ^ "Mouse Genome Informatics".
  12. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  13. ^ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  14. ^ Collins FS, Rossant J, Wurst W (2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  15. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  16. ^ Soond SM, Terry JL, Colbert JD, Riches DW (Nov 2003). "TRUSS, a novel tumor necrosis factor receptor 1 scaffolding protein that mediates activation of the transcription factor NF-kappaB". Mol. Cell. Biol. 23 (22): 8334–44. doi:10.1128/MCB.23.22.8334-8344.2003. PMC 262424. PMID 14585990.