Trpc4-associated protein is a protein that in humans is encoded by the TRPC4AP gene.
Model organisms [ edit ] Model organisms have been used in the study of TRPC4AP function. A conditional knockout mouse line, called Trpc4ap tm1a(KOMP)Wtsi  was generated as part of the  International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.  
Male and female animals underwent a standardized
phenotypic screen to determine the effects of deletion.  Twenty five tests were carried out on  mutant mice and three significant abnormalities were observed. Few  homozygous mutant embryos were identified during gestation, and thus fewer than expected survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; females had an abnormal anagen phase of the hair cycle.
Interactions [ edit ]
TRPC4AP has been shown to
interact with TNFRSF1A.
See also [ edit ]
Further reading [ edit ]
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References [ edit ]
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GRCh38: Ensembl release 89: ENSG00000100991 - Ensembl, May 2017
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GRCm38: Ensembl release 89: ENSMUSG00000038324 - Ensembl, May 2017
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". Wellcome Trust Sanger Institute. Citrobacter infection data for Trpc4ap"
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Mouse Resources Portal, Wellcome Trust Sanger Institute.
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"Mouse Genome Informatics".
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