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Aliases TRPC6, FSGS2, TRP6, transient receptor potential cation channel subfamily C member 6
External IDs OMIM: 603652 MGI: 109523 HomoloGene: 37944 GeneCards: 7225
Targeted by Drug
20-HETE, arachidonic acid, 2-APB, Hydron[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 11: 101.45 – 101.87 Mb Chr 9: 8.54 – 8.68 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of the same name. TRPC6 is a transient receptor potential ion channel. It has been associated with depression and anxiety (see below), as well as with focal segmental glomerulosclerosis (FSGS).[4]


TRPC6 has been shown to interact with:


Two of the primary active constituents responsible for the antidepressant and anxiolytic benefits of Hypericum perforatum, also known as St. John's Wort, are hyperforin and adhyperforin.[8][9] These compounds are inhibitors of the reuptake of serotonin, norepinephrine, dopamine, γ-aminobutyric acid, and glutamate, and they exert these effects by binding to and activating TRPC6.[9][10] Activation of TRPC6 induces the entry of Ca2+ and Na+ into the cell, which results in the inhibition of reuptake.[10]


  1. ^ "Drugs that physically interact with Short transient receptor potential channel 6 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB (2005). "A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis". Science. 308 (5729): 1801–4. doi:10.1126/science.1106215. PMID 15879175. 
  5. ^ Hisatsune C, Kuroda Y, Nakamura K, Inoue T, Nakamura T, Michikawa T, Mizutani A, Mikoshiba K (Apr 2004). "Regulation of TRPC6 channel activity by tyrosine phosphorylation". J. Biol. Chem. 279 (18): 18887–94. doi:10.1074/jbc.M311274200. PMID 14761972. 
  6. ^ Chu X, Tong Q, Cheung JY, Wozney J, Conrad K, Mazack V, Zhang W, Stahl R, Barber DL, Miller BA (March 2004). "Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx". J. Biol. Chem. 279 (11): 10514–22. doi:10.1074/jbc.M308478200. PMID 14699131. 
  7. ^ Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7461–6. doi:10.1073/pnas.102596199. PMC 124253free to read. PMID 12032305. 
  8. ^ Müller WE, Singer A, Wonnemann M (2001). "Hyperforin--antidepressant activity by a novel mechanism of action". Pharmacopsychiatry. 34 Suppl 1: S98–102. doi:10.1055/s-2001-15512. PMID 11518085. 
  9. ^ a b Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Müller WE (1998). "Hyperforin as a possible antidepressant component of hypericum extracts". Life Sci. 63 (6): 499–510. doi:10.1016/S0024-3205(98)00299-9. PMID 9718074. 
  10. ^ a b Leuner K, Kazanski V, Müller M, Essin K, Henke B, Gollasch M, Harteneck C, Müller WE (December 2007). "Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels". FASEB J. 21 (14): 4101–11. doi:10.1096/fj.07-8110com. PMID 17666455. 

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