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Aliases TRPM3, GON-2, LTRPC3, MLSN2, transient receptor potential cation channel subfamily M member 3
External IDs MGI: 2443101 HomoloGene: 62287 GeneCards: 80036
RNA expression pattern
PBB GE TRPM3 211422 at tn.png

PBB GE TRPM3 216452 at tn.png

PBB GE TRPM3 220463 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)
RefSeq (protein)



Location (UCSC) Chr 9: 70.53 – 71.45 Mb Chr 19: 22.14 – 22.99 Mb
PubMed search [1] [2]
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Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.[3]

The product of this gene belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation-selective channels important for cellular calcium signaling and homeostasis. The protein encoded by this gene mediates calcium entry, and this entry is potentiated by calcium store depletion. Alternatively spliced transcript variants encoding different isoforms have been -identified.[4] TRPM3 was shown to be activated by the neurosteroid pregnenolone sulphate in pancreatic beta cell. The activation causes calcium influx and subsequent insulin release, therefore it is suggested that TRPM3 modulates glucose homeostasis.[5]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Clapham DE, Julius D, Montell C, Schultz G (Dec 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  4. ^ "Entrez Gene: TRPM3 transient receptor potential cation channel, subfamily M, member 3". 
  5. ^ Wagner TF, Loch S, Lambert S, et al. (November 2008). "Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells". Nature Cell Biology. 10 (12): 1421–30. doi:10.1038/ncb1801. PMID 18978782. 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.