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Transient receptor potential cation channel, subfamily M, member 6
External IDs OMIM607009 MGI2675603 HomoloGene9767 IUPHAR: 498 ChEMBL: 1628470 GeneCards: TRPM6 Gene
EC number
RNA expression pattern
PBB GE TRPM6 221102 s at tn.png
More reference expression data
Species Human Mouse
Entrez 140803 225997
Ensembl ENSG00000119121 ENSMUSG00000024727
UniProt Q9BX84 Q8CIR4
RefSeq (mRNA) NM_001177310 NM_153417
RefSeq (protein) NP_001170781 NP_700466
Location (UCSC) Chr 9:
74.72 – 74.89 Mb
Chr 19:
18.75 – 18.89 Mb
PubMed search [1] [2]

TRPM6 is a transient receptor potential ion channel associated with hypomagnesemia with secondary hypocalcemia.[1]

See also[edit]


  1. ^ Schlingmann KP, Weber S, Peters M, et al. (2002). "Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family". Nat. Genet. 31 (2): 166–70. doi:10.1038/ng889. PMID 12032568. 

Further reading[edit]

  • Islam, Md. Shahidul (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6. 
  • Chubanov V, Gudermann T, Schlingmann KP (2006). "Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis.". Pflugers Arch. 451 (1): 228–34. doi:10.1007/s00424-005-1470-y. PMID 16075242. 
  • Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  • Bödding M (2007). "TRPM6: A Janus-like protein.". Handb Exp Pharmacol 179 (179): 299–311. doi:10.1007/978-3-540-34891-7_18. PMID 17217065. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.