TSC22D3

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TSC22D3
Protein TSC22D3 PDB 1dip.png
Identifiers
Aliases TSC22D3, DIP, DSIPI, GILZ, TSC-22R, hDIP, TSC22 domain family member 3
External IDs MGI: 1196284 HomoloGene: 104035 GeneCards: TSC22D3
RNA expression pattern
PBB GE TSC22D3 208763 s at fs.png

PBB GE TSC22D3 207001 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001015881
NM_004089
NM_198057
NM_001318468
NM_001318470

NM_001077364
NM_010286

RefSeq (protein)

NP_001015881
NP_001305397
NP_001305399
NP_004080
NP_932174

NP_001070832.1
NP_034416.3
NP_001070832
NP_034416

Location (UCSC) Chr X: 107.71 – 107.78 Mb Chr X: 140.54 – 140.6 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

TSC22 domain family protein 3 is a protein that in humans is encoded by the TSC22D3 gene.[3][4]

Function[edit]

The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. GILZ shows ubiquitous expression across tissues, including thymus, spleen, lung, fat, liver, kidney, heart, and skeletal muscle.[5][6] The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.[4]

Interactions[edit]

TSC22D3 has been shown to interact with C-Raf,[7] NFKB2[8] and NFKB1.[8]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Vogel P, Mägert HJ, Cieslak A, Adermann K, Forssmann WG (Dec 1996). "hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues". Biochimica et Biophysica Acta. 1309 (3): 200–4. doi:10.1016/s0167-4781(96)00177-7. PMID 8982256. 
  4. ^ a b "Entrez Gene: TSC22D3 TSC22 domain family, member 3". 
  5. ^ Ayyar, Vivaswath S.; Almon, Richard R.; Jusko, William J.; DuBois, Debra C. (2015-06-01). "Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids". Physiological Reports. 3 (6). doi:10.14814/phy2.12382. PMC 4510616Freely accessible. PMID 26056061. 
  6. ^ Cannarile, L.; Zollo, O.; D'Adamio, F.; Ayroldi, E.; Marchetti, C.; Tabilio, A.; Bruscoli, S.; Riccardi, C. (2001-02-01). "Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene". Cell Death and Differentiation. 8 (2): 201–203. doi:10.1038/sj.cdd.4400798. ISSN 1350-9047. PMID 11313722. 
  7. ^ Ayroldi E, Zollo O, Macchiarulo A, Di Marco B, Marchetti C, Riccardi C (Nov 2002). "Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1". Molecular and Cellular Biology. 22 (22): 7929–41. doi:10.1128/MCB.22.22.7929-7941.2002. PMC 134721Freely accessible. PMID 12391160. 
  8. ^ a b Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C (Aug 2001). "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB". Blood. 98 (3): 743–53. doi:10.1182/blood.V98.3.743. PMID 11468175. 

Further reading[edit]