TSEN2

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TSEN2
Identifiers
Aliases TSEN2, PCH2B, SEN2, SEN2L, tRNA splicing endonuclease subunit 2
External IDs MGI: 2141599 HomoloGene: 41622 GeneCards: TSEN2
Genetically Related Diseases
prostate cancer[1]
RNA expression pattern
PBB GE TSEN2 219581 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_199033

RefSeq (protein)

NP_950198.1
NP_950198

Location (UCSC) Chr 3: 12.48 – 12.54 Mb Chr 6: 115.54 – 115.58 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

tRNA-splicing endonuclease subunit Sen2 is an enzyme that in humans is encoded by the TSEN2 gene.[4][5]

tRNA splicing is a fundamental process required for cell growth and division. SEN2 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns, the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][5]

Interactions[edit]

TSEN2 has been shown to interact with TSEN34[4] and C1orf19.[4]

References[edit]

  1. ^ "Diseases that are genetically associated with TSEN2 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b c Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (Apr 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation". Cell. 117 (3): 311–21. doi:10.1016/S0092-8674(04)00342-3. PMID 15109492. 
  5. ^ a b "Entrez Gene: TSEN2 tRNA splicing endonuclease 2 homolog (S. cerevisiae)". 

External links[edit]

Further reading[edit]