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Tetraspanin 7
Symbols TSPAN7 ; A15; CCG-B7; CD231; DXS1692E; MRX58; MXS1; TALLA-1; TM4SF2; TM4SF2b
External IDs OMIM300096 MGI1298407 HomoloGene20967 GeneCards: TSPAN7 Gene
RNA expression pattern
PBB GE TSPAN7 202242 at tn.png
More reference expression data
Species Human Mouse
Entrez 7102 21912
Ensembl ENSG00000156298 ENSMUSG00000058254
UniProt P41732 Q62283
RefSeq (mRNA) NM_004615 NM_019634
RefSeq (protein) NP_004606 NP_062608
Location (UCSC) Chr X:
38.56 – 38.69 Mb
Chr X:
10.49 – 10.6 Mb
PubMed search [1] [2]

Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy.[2]


  1. ^ Abidi FE, Holinski-Feder E, Rittinger O, Kooy F, Lubs HA, Stevenson RE, Schwartz CE (Jun 2002). "A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58". J Med Genet 39 (6): 430–3. doi:10.1136/jmg.39.6.430. PMC 1735161. PMID 12070254. 
  2. ^ a b "Entrez Gene: TSPAN7 tetraspanin 7". 

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