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Tissue specific transplantation antigen P35B
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TSTA3 ; FX; P35B; SDR4E1
External IDs OMIM137020 MGI98857 HomoloGene2484 GeneCards: TSTA3 Gene
EC number
RNA expression pattern
PBB GE TSTA3 36936 at tn.png
PBB GE TSTA3 201644 at tn.png
More reference expression data
Species Human Mouse
Entrez 7264 22122
Ensembl ENSG00000104522 ENSMUSG00000022570
UniProt Q13630 P23591
RefSeq (mRNA) NM_003313 NM_031201
RefSeq (protein) NP_003304 NP_112478
Location (UCSC) Chr 8:
143.61 – 143.62 Mb
Chr 15:
75.92 – 75.93 Mb
PubMed search [1] [2]

GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene.[1][2][3][4]

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II.[4]


  1. ^ Camardella L, Carratore V, Ciardiello MA, Damonte G, Benatti U, De Flora A (Feb 1995). "Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B". Blood 85 (1): 264–7. PMID 7803801. 
  2. ^ Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL, Boon T (May 1992). "Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198". Immunogenetics 35 (5): 316–23. doi:10.1007/bf00189894. PMID 1348494. 
  3. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726. 
  4. ^ a b "Entrez Gene: TSTA3 tissue specific transplantation antigen P35B". 

Further reading[edit]