TSTA3

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TSTA3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TSTA3, FX, P35B, SDR4E1, tissue specific transplantation antigen P35B
External IDs MGI: 98857 HomoloGene: 2484 GeneCards: TSTA3
RNA expression pattern
PBB GE TSTA3 36936 at fs.png

PBB GE TSTA3 201644 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003313
NM_001317783

NM_031201

RefSeq (protein)

NP_001304712
NP_003304

NP_112478.1
NP_112478

Location (UCSC) Chr 8: 143.61 – 143.62 Mb Chr 15: 75.92 – 75.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene.[3][4][5][6]

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Camardella L, Carratore V, Ciardiello MA, Damonte G, Benatti U, De Flora A (Feb 1995). "Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B". Blood. 85 (1): 264–7. PMID 7803801. 
  4. ^ Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL, Boon T (May 1992). "Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198". Immunogenetics. 35 (5): 316–23. doi:10.1007/bf00189894. PMID 1348494. 
  5. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744Freely accessible. PMID 19027726. 
  6. ^ a b "Entrez Gene: TSTA3 tissue specific transplantation antigen P35B". 

Further reading[edit]