TTF2

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TTF2
Identifiers
Aliases TTF2, HuF2, ZGRF6, transcription termination factor, RNA polymerase II, transcription termination factor 2
External IDs MGI: 1921294 HomoloGene: 37826 GeneCards: TTF2
RNA expression pattern
PBB GE TTF2 204407 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003594

NM_001013026

RefSeq (protein)

NP_003585

NP_001013044.2
NP_001013044

Location (UCSC) Chr 1: 117.06 – 117.11 Mb Chr 3: 100.94 – 100.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.[3][4]

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.[4]

Interactions[edit]

TTF2 has been shown to interact with CDC5L.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Liu M, Xie Z, Price DH (Nov 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member". J Biol Chem. 273 (40): 25541–4. doi:10.1074/jbc.273.40.25541. PMID 9748214. 
  4. ^ a b "Entrez Gene: TTF2 transcription termination factor, RNA polymerase II". 
  5. ^ Leonard, Deana; Ajuh Paul; Lamond Angus I; Legerski Randy J (Sep 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. United States. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. ISSN 0006-291X. PMID 12927788. 

Further reading[edit]