TUBA1A

From Wikipedia, the free encyclopedia
Jump to: navigation, search
TUBA1A
Protein TUBA1A PDB 1ffx.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TUBA1A, B-ALPHA-1, LIS3, TUBA3, tubulin alpha 1a
External IDs MGI: 98869 HomoloGene: 68498 GeneCards: 7846
RNA expression pattern
PBB GE TUBA1A 201090 x at tn.png

PBB GE TUBA1A 209118 s at tn.png

PBB GE TUBA1A 209251 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006009
NM_001270399
NM_001270400

NM_011653

RefSeq (protein)

NP_001257328.1
NP_001257329.1
NP_006000.2

NP_035783.1

Location (UCSC) Chr 12: 49.18 – 49.19 Mb Chr 15: 98.95 – 98.95 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tubulin alpha-1A chain is a protein that in humans is encoded by the TUBA1A gene.[3][4][5]

Function[edit]

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.[5]

Interactions[edit]

TUBA1A has been shown to interact with PAFAH1B1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Crabtree DV, Ojima I, Geng X, Adler AJ (August 2001). "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site". Bioorganic & Medicinal Chemistry. 9 (8): 1967–76. doi:10.1016/S0968-0896(01)00103-1. PMID 11504633. 
  4. ^ Hall JL, Cowan NJ (January 1985). "Structural features and restricted expression of a human alpha-tubulin gene". Nucleic Acids Research. 13 (1): 207–23. doi:10.1093/nar/13.1.207. PMC 340985free to read. PMID 3839072. 
  5. ^ a b "Entrez Gene: TUBA1A tubulin, alpha 1a". 
  6. ^ Sapir T, Elbaum M, Reiner O (December 1997). "Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit". The EMBO Journal. 16 (23): 6977–84. doi:10.1093/emboj/16.23.6977. PMC 1170301free to read. PMID 9384577. 

Further reading[edit]