TUBA1B

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TUBA1B
Protein TUBA1B PDB 1ffx.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTUBA1B, K-ALPHA-1, tubulin alpha 1b
External IDsOMIM: 602530 MGI: 107804 HomoloGene: 134527 GeneCards: TUBA1B
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for TUBA1B
Genomic location for TUBA1B
Band12q13.12Start49,127,782 bp[1]
End49,131,397 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006082

NM_011654

RefSeq (protein)

NP_006073

NP_035784

Location (UCSC)Chr 12: 49.13 – 49.13 MbChr 15: 98.93 – 98.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.[5][6][7]


Interactions[edit]

TUBA1B has been shown to interact with PIK3R1.[8] Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123416 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023004 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Banerjee A (Jun 2002). "Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells". Biochem Biophys Res Commun. 293 (1): 598–601. doi:10.1016/S0006-291X(02)00269-3. PMID 12054644.
  6. ^ Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (Jan 1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol Cell Biol. 3 (10): 1738–45. doi:10.1128/mcb.3.10.1738. PMC 370035. PMID 6646120.
  7. ^ "Entrez Gene: TUBA1B tubulin, alpha 1b".
  8. ^ Kapeller, R; Toker A; Cantley L C; Carpenter C L (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". J. Biol. Chem. UNITED STATES. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. ISSN 0021-9258. PMID 7592789.
  9. ^ https://www.genetex.com/Product/Detail/alpha-Tubulin-antibody-GT114/GTX628802

Further reading[edit]

External links[edit]