TUBA1B

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TUBA1B
Protein TUBA1B PDB 1ffx.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TUBA1B, K-ALPHA-1, tubulin alpha 1b
External IDs MGI: 107804 HomoloGene: 134527 GeneCards: TUBA1B
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for TUBA1B
Genomic location for TUBA1B
Band 12q13.12 Start 49,127,782 bp[1]
End 49,131,397 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006082

NM_011654

RefSeq (protein)

NP_006073

NP_035784

Location (UCSC) Chr 12: 49.13 – 49.13 Mb Chr 12: 98.93 – 98.93 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.[5][6][7]


Interactions[edit]

TUBA1B has been shown to interact with PIK3R1.[8] Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123416 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023004 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Banerjee A (Jun 2002). "Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells". Biochem Biophys Res Commun. 293 (1): 598–601. doi:10.1016/S0006-291X(02)00269-3. PMID 12054644. 
  6. ^ Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (Jan 1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol Cell Biol. 3 (10): 1738–45. PMC 370035Freely accessible. PMID 6646120. 
  7. ^ "Entrez Gene: TUBA1B tubulin, alpha 1b". 
  8. ^ Kapeller, R; Toker A; Cantley L C; Carpenter C L (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". J. Biol. Chem. UNITED STATES. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. ISSN 0021-9258. PMID 7592789. 
  9. ^ http://www.genetex.com/WebPage/Product/PromotionDetail.aspx?Type=Promotion&PromotionID=178

Further reading[edit]

External links[edit]