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Tubulin, alpha 4a
Protein TUBA4A PDB 1ffx.png
PDB rendering based on 1ffx.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TUBA4A ; ALS22; H2-ALPHA; TUBA1
External IDs OMIM191110 MGI1095410 HomoloGene68496 ChEMBL: 2070 GeneCards: TUBA4A Gene
RNA expression pattern
PBB GE TUBA4A 212242 at tn.png
More reference expression data
Species Human Mouse
Entrez 7277 22145
Ensembl ENSG00000127824 ENSMUSG00000026202
UniProt P68366 P68368
RefSeq (mRNA) NM_001278552 NM_009447
RefSeq (protein) NP_001265481 NP_033473
Location (UCSC) Chr 2:
219.25 – 219.28 Mb
Chr 1:
75.21 – 75.22 Mb
PubMed search [1] [2]

Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene.[1]


Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.[2]


TUBA4A has been shown to interact with NCOA6[3] and APC.[4]


  1. ^ Villasante A, Wang D, Dobner P, Dolph P, Lewis SA, Cowan NJ (Jul 1986). "Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes". Molecular and Cellular Biology 6 (7): 2409–19. doi:10.1128/mcb.6.7.2409. PMC 367794. PMID 3785200. 
  2. ^ "Entrez Gene: TUBA4A tubulin, alpha 4a". 
  3. ^ Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670. PMID 12482968. 
  4. ^ Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS (Jan 2001). "Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation". Current Biology 11 (1): 44–9. doi:10.1016/S0960-9822(01)00002-1. PMID 11166179. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.