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For persons named Tubb, see Tubb.
Protein TUBB PDB 1ffx.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TUBB, CDCBM6, M40, OK/SW-cl.56, TUBB1, TUBB5, CSCSC1, tubulin beta class I
External IDs MGI: 107812 HomoloGene: 69099 GeneCards: TUBB
Targeted by Drug
cabazitaxel, docetaxel anhydrous, eribulin, ixabepilone, paclitaxel, vincristine[1]
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 6: 30.72 – 30.73 Mb Chr 17: 35.83 – 35.84 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Tubulin beta chain is a protein that in humans is encoded by the TUBB gene.[4][5][6]


TUBB has been shown to interact with NCOA6[7] and SYT9.[8]

See also[edit]


  1. ^ "Drugs that physically interact with Tubulin beta class I view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Crabtree DV, Ojima I, Geng X, Adler AJ (Aug 2001). "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site". Bioorganic & Medicinal Chemistry. 9 (8): 1967–76. doi:10.1016/S0968-0896(01)00103-1. PMID 11504633. 
  5. ^ Volz A, Weiss E, Trowsdale J, Ziegler A (Jan 1994). "Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction". Human Genetics. 93 (1): 42–6. doi:10.1007/BF00218911. PMID 8270253. 
  6. ^ "Entrez Gene: TUBB tubulin, beta". 
  7. ^ Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670Freely accessible. PMID 12482968. 
  8. ^ Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166. 

Further reading[edit]