TWIST2

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TWIST2
Identifiers
Aliases TWIST2, DERMO1, FFDD3, SETLSS, bHLHa39, AMS, BBRSAY, twist family bHLH transcription factor 2
External IDs MGI: 104685 HomoloGene: 40594 GeneCards: TWIST2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001271893
NM_057179

NM_007855

RefSeq (protein)

NP_001258822
NP_476527

NP_031881.1
NP_031881

Location (UCSC) Chr 2: 238.85 – 238.91 Mb Chr 1: 91.8 – 91.85 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Twist-related protein 2 is a protein that in humans is encoded by the TWIST2 gene.[3][4][5]

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Twist. It is thought that during osteoblast development this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype.[5]

Interactions[edit]

TWIST2 has been shown to interact with SREBF1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Li L, Cserjesi P, Olson EN (Dec 1995). "Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis". Dev Biol. 172 (1): 280–92. doi:10.1006/dbio.1995.0023. PMID 7589808. 
  4. ^ Perrin-Schmitt F, Bolcato-Bellemin AL, Bourgeois P, Stoetzel C, Danse JM (Apr 1997). "The locations of the H-twist and H-dermo-1 genes are distinct on the human genome". Biochim Biophys Acta. 1360 (1): 1–2. doi:10.1016/s0925-4439(96)00071-3. PMID 9061034. 
  5. ^ a b "Entrez Gene: TWIST2 twist homolog 2 (Drosophila)". 
  6. ^ Lee, Yun Sok; Lee Hyoung Ho; Park Jiyoung; Yoo Eung Jae; Glackin Carlotta A; Choi Young Il; Jeon Sung Ho; Seong Rho Hyun; Park Sang Dai; Kim Jae Bum (Dec 2003). "Twist2, a novel ADD1/SREBP1c interacting protein, represses the transcriptional activity of ADD1/SREBP1c". Nucleic Acids Res. England. 31 (24): 7165–74. doi:10.1093/nar/gkg934. PMC 291873Freely accessible. PMID 14654692. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.