From Wikipedia, the free encyclopedia
Jump to: navigation, search
Thioredoxin domain containing 5 (endoplasmic reticulum)
Protein TXNDC5 PDB 2diz.png
PDB rendering based on 2diz.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TXNDC5 ; ENDOPDI; ERP46; HCC-2; HCC2; PDIA15; STRF8; UNQ364
External IDs OMIM616412 MGI2145316 HomoloGene11125 GeneCards: TXNDC5 Gene
Species Human Mouse
Entrez 81567 105245
Ensembl ENSG00000239264 ENSMUSG00000038991
UniProt Q8NBS9 Q91W90
RefSeq (mRNA) NM_001145549 NM_001289598
RefSeq (protein) NP_001139021 NP_001276527
Location (UCSC) Chr 6:
7.88 – 7.91 Mb
Chr 13:
38.5 – 38.53 Mb
PubMed search [1] [2]

Thioredoxin domain-containing protein 5 is a protein that in humans is encoded by the TXNDC5 gene.[1]


This gene encodes a protein disulfide-isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MUTED.[1]


Further reading[edit]