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Monoclonal antibody
Type Whole antibody
Source Human
Target BAFF
Clinical data
ATC code
  • none
CAS Number
  • none
Chemical and physical data
Formula C6518H10008N1724O2032S38
Molar mass 146.25 kg/mol
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Tabalumab (LY 2127399) is an anti-B-cell activating factor (BAFF) human monoclonal antibody designed for the treatment of autoimmune diseases and B cell malignancies.[1][2] Tabalumab was developed by Eli Lilly and Company.

A phase III clinical trial for rheumatoid arthritis was halted in Feb 2013.[3] In September 2014, a second phase III trial focussing on treating systemic lupus erythematosus, was terminated early as the study failed to meet its primary endpoint.[4]


Now dropped by Lilly due to lack of efficacy.