Tachykinin receptor

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tachykinin receptor 1
Identifiers
SymbolTACR1
Alt. symbolsTAC1R
Entrez6869
HUGO11526
OMIM162323
RefSeqNM_001058
UniProtP25103
Other data
LocusChr. 2 p13.1-p12
tachykinin receptor 2
Identifiers
SymbolTACR2
Alt. symbolsTAC2R, NKNAR
Entrez6865
HUGO11527
OMIM162321
RefSeqNM_001057
UniProtP21452
Other data
LocusChr. 10 q11-q21
tachykinin receptor 3
Identifiers
SymbolTACR3
Entrez6870
HUGO11528
OMIM162332
RefSeqNM_001059
UniProtP29371
Other data
LocusChr. 4 q25

There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).

Binding[edit]

The genes and receptor ligands are as follows:[1]

Receptor Gene Preferred ligand
NK1 TACR1 substance P
NK2 TACR2 neurokinin A
NK3 TACR3 neurokinin B

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

See also[edit]

References[edit]

  1. ^ Maggi CA (September 1995). "The mammalian tachykinin receptors". General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.

External links[edit]