Tachykinin receptor 2

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Tachykinin receptor 2
External IDs OMIM162321 MGI98477 HomoloGene55548 IUPHAR: 361 ChEMBL: 2327 GeneCards: TACR2 Gene
RNA expression pattern
PBB GE TACR2 214348 at tn.png
More reference expression data
Species Human Mouse
Entrez 6865 21337
Ensembl ENSG00000075073 ENSMUSG00000020081
UniProt P21452 P30549
RefSeq (mRNA) NM_001057 NM_009314
RefSeq (protein) NP_001048 NP_033340
Location (UCSC) Chr 10:
69.4 – 69.42 Mb
Chr 10:
62.25 – 62.27 Mb
PubMed search [1] [2]

Substance-K receptor is a protein that in humans is encoded by the TACR2 gene.[1]

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A.[1]

Selective Ligands[edit]

Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an anxiolytic and antidepressant.


  • GR-64349 - potent and selective agonist, EC50 3.7nM, 7-amino acid polypeptide chain. CAS# 137593-52-3


See also[edit]


External links[edit]

  • "Tachykinin Receptors: NK2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.