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Talampanel skeletal.svg
Clinical data
ATC code
  • none
Legal status
Legal status
  • Investigational
CAS Number
PubChem CID
ECHA InfoCard 100.230.001
Chemical and physical data
Formula C19H19N3O3
Molar mass 337.372 g/mol
3D model (JSmol)
 NYesY (what is this?)  (verify)

Talampanel (INN) (code names GYKI 537773, LY300164) is a drug which has been investigated for the treatment of epilepsy,[1][2] malignant gliomas[3] and amyotrophic lateral sclerosis (ALS).[4]

As of May 2010, results from the trial for ALS have been found negative.[5] Talampanel is not currently under development.

Talampanel acts as a non-competitive antagonist of the AMPA receptor, a type of glutamate receptor in the central nervous system.[6]


  1. ^ Luszczki, J. J. (2009). "Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions". Pharmacological reports : PR. 61 (2): 197–216. PMID 19443931. doi:10.1016/s1734-1140(09)70024-6. 
  2. ^ Bialer, M.; Johannessen, S. I.; Kupferberg, H. J.; Levy, R. H.; Perucca, E.; Tomson, T. R. (2007). "Progress report on new antiepileptic drugs: A summary of the Eighth Eilat Conference (EILAT VIII)". Epilepsy Research. 73 (1): 1–52. PMID 17158031. doi:10.1016/j.eplepsyres.2006.10.008. 
  3. ^ Iwamoto, F. M.; Kreisl, T. N.; Kim, L.; Duic, J. P.; Butman, J. A.; Albert, P. S.; Fine, H. A. (2010). "Phase II Trial of Talampanel, a Glutamate Receptor Inhibitor, for Adults with Recurrent Malignant Gliomas". Cancer. 116 (7): 1776–1782. PMC 2846997Freely accessible. PMID 20143438. doi:10.1002/cncr.24957. 
  4. ^ Pascuzzi, R. M.; Shefner, J.; Chappell, A. S.; Bjerke, J. S.; Tamura, R.; Chaudhry, V.; Clawson, L.; Haas, L.; Rothstein, J. D. (2009). "A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis". Amyotrophic Lateral Sclerosis. 11 (3): 266–271. PMID 19961264. doi:10.3109/17482960903307805. 
  5. ^ Talampanel Trial, Talampanel Trial on alsa.org
  6. ^ Aujla, P. K.; Fetell, M. R.; Jensen, F. E. (2009). "Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model". Epilepsia. 50 (4): 694–701. PMC 2672962Freely accessible. PMID 19220413. doi:10.1111/j.1528-1167.2008.01947.x.