Talastine

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Talastine
Talastine.png
Clinical data
ATC code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H21N3O
Molar mass307.39 g/mol g·mol−1
3D model (JSmol)
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Talastine (trade name Ahanon) is an antihistamine.[1]

Synthesis[edit]

The amide proton from 4-Benzylphalazone is abstracted with KOH, which is then alkylated with diethylaminoethyl chloride.[2]

References[edit]

  1. ^ Richter, G.; Kühn, E. (1990). "Talastine (Ahanon) as a cause of allergic drug exanthema". Dermatologische Monatsschrift. 176 (2–3): 111–113. PMID 1973126.
  2. ^ Engelbrecht et al., DE 1046625 ; eidem, U.S. Patent 3,017,411 (1958, 1962, both to VEB Deutsches Hydrierwerk Rodleben).

External links[edit]