Talastine

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Talastine
Talastine.png
Systematic (IUPAC) name
4-benzyl-2-[2-(dimethylamino)ethyl]phthalazin-1(2H)-one
Identifiers
CAS Number 16188-61-7 YesY
ATC code R06AB07 (WHO)
PubChem CID 65624
ChemSpider 59065 YesY
UNII 49AB2PA48B YesY
Chemical data
Formula C19H21N3O
Molar mass 307.39 g/mol
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Talastine (trade name Ahanon) is an antihistamine.[1]

Synthesis[edit]

The amide proton from 4-Benzylphalazone is abstracted with KOH, which is then alkylated with diethylaminoethyl chloride.[2]

References[edit]

  1. ^ Richter, G.; Kühn, E. (1990). "Talastine (Ahanon) as a cause of allergic drug exanthema". Dermatologische Monatschrift 176 (2–3): 111–113. PMID 1973126. 
  2. ^ Engelbrecht et al., DE 1046625 ; eidem, U.S. Patent 3,017,411 (1958, 1962, both to VEB Deutsches Hydrierwerk Rodleben).

External links[edit]