|WikiProject Molecular and Cell Biology||(Rated B-class, Mid-importance)|
Nomenclature and History of 5-HT receptors
The history written here (ie about the M and D nomenclature) is general about all the 5-HT receptors and talks only of a very old accidental/spurious nomenclature which was used probably in the 1950's. We should better clean up that part and if that becomes big move it to the serotonin receptor general article with only a brief mention here. More importantly we need to put the specific parts of the 5-HT receptors history relevant to this receptor. eg in the 1994 nomenclature review, Hoyer first proposed that the erstwhile 5-HT2 now be called 5-HT2A, and the erstwhile 5-HT1C be renamed 5-HT2C sinec the 5-HT2C was found to be structurally much closer to the 5-HT2. <ref> Hoyer, D, Clarke, DE, Fozard, JR, Hartig, PR, Martin, GR, Mylecharane, EJ, Saxena, PR, Humphrey, PP International Union of Pharmacology classification of receptors for 5- hydroxytryptamine (Serotonin) Pharmacol Rev 1994 46: 157-203</ref>.
To quote the 1994 article:
"Until recently, there was no compelling evidence to subdivide 5-HT2 receptors which are widespread and mediate many of the actions of 5-HT throughout the body (Leysen et a!., 1983; Mylecharane, 1990). However, the close structural homology of the 5-HT1C receptor with the 5-HT2 receptor, together with a shared second messenger transduction system and very similar operational characteristics, does clearly indicate that the 5-HT1C receptor should now be considered as a 5-HT2 subtype (Hoyer, 1988a; Hartig, 1989). With this in mind, we have recommended that it should now be called the 5-HT2C receptor (see section III). This makes it possible to call the “classical” 5-HT2 receptor 5-HTı and the newly sequenced rat stomach fundus 5-HT receptor the 5-HT2B receptor (Foguet et a!., 1992a,b), instead of the term 5-HT2F (Kursar et al., 1992)."
We might have the older bif of the history as well. But since the people dealing with the spurious pharmacological coincidences were themselves baffled, we should clarify those facts in the light of later cloning data and clear the puzzle for them. -- —The preceding unsigned comment was added by Dr.saptarshi (talk • contribs) 23:32, 28 February 2007 (UTC).
Why is Risperidone the only one mentioned? Don't almost all or all of the atypicals antagonise the 5HT2A receptor? Why not just say that the group of atypicals antagonises this receptor? —The preceding unsigned comment was added by 188.8.131.52 (talk) 22:27, 14 March 2007 (UTC).
Yes, Seroquel, Zyprexa and most other modern antipsychotics are 5-HT2A blockers.
Excess 5-HT2A receptors can cause problems which is reduced by increasing TNF-a receptors with chili or by using 5-HT2A agonists. — Preceding unsigned comment added by 184.108.40.206 (talk) 00:04, 3 September 2012 (UTC)
5-HT2 agonists and long term memory
Why don't you do so yourself? Also, what leads you to believe they can have positive effects on memory? A quick search leads me to animal studies which seem to suggest that 5-HT2 agonists might actually impair short-term memory and, at a dosage high enough, long-term memory. Erik.Bjareholt (talk) 20:59, 24 January 2015 (UTC)