Talk:5-HT receptor

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Gepiron and ipsapiron are also 5HT1A receptor activators

I replaced "mirtazepine" for "mirtazapine", which is a more common spelling and has an article under it. - Ktai 08:56, 15 October 2006 (UTC)

Linking to this page[edit]

I've seen many pages with references to various 5-HT receptors, particularly in the pharmaceutical and hallucinogenic substance area since that is the area i most frequent, and rarely do i come upon links to this page. In fact i have just discovered this article. I think it'd be appropriate to work on adding this page as a link to the articles in which the references to 5-HT*'s are not linked to anything, so if one might see this i urge you to add the page as a link.--Neur0X .talk 04:59, 25 December 2006 (UTC)

or possibly just merge the page[edit]

its is quite a large page already so it might be better off separated. If some one was to write separate articles for the sub categories of 5-HT then it could be left alone and linked to as a sub category —The preceding unsigned comment was added by (talk) 14:00, 7 March 2007 (UTC).

LSD as a 5-HT2A agonist AND antagonist?[edit]


I believe there's been an error. LSD is listed as a 5-HT2A agonist and antagonist, both. This should be impossible, but I'm wary about changing the article without an actual chemist's say on it. (I believe it should be agonist only.) 05:16, 16 September 2007 (UTC)

  • You are correct as documented here. LSD is a 5-HT2A agonist whose effects can be blocked by 5-HT2A antagonists. I have therefore removed LSD from the 5-HT2A antagonist list. Boghog2 08:02, 16 September 2007 (UTC)
  • After more careful reading of the article, LSD is listed as an agonist in the CNS and antagonist in the peripheral nervous system which is possible. There are early reports that LSD acts as antagonist in peripheral tissues [Gaddum JH (1953). "Antagonism between lysergic acid diethylamide and 5-hydroxytryptamine". J. Physiol. (Lond.). 121 (1): 15P. PMID 13085323. ], but I cannot find any references specifically mentioning that LSD is a peripheral 5-HT2A antagonist. So I will leave the list as is for now. Boghog2 08:38, 16 September 2007 (UTC)

5-HT5 Receptor[edit]

Article lists as Gi-coupled, my sources say it's Gs-coupled. This should be confirmed. Snellios (talk) 10:18, 28 April 2008 (UTC)


It would be great to include where different 5HT receptors are most densely located. For example, from the article The interaction between the internal clock and antidepressant efficacy by Racagni: "There is a high density of 5-HT2C receptors within the suprachiasmatic nucleus". —Preceding unsigned comment added by (talk) 17:06, 18 February 2009 (UTC)


A helpful mnemonic for remembering the coupling may be 5ht-2 Gq, 1 and 5 Gi, all the rest Gs. 3 is G-free. This helps me to remember the coupling, since it is useful information I think it should be added to the page somehow. My previous addition got undone so I figure If its going to be controversal somehow it should go here. I mean the page on the cranial nerves has a bunch of mnemonics, which I found very useful. Ultimately I think adding useful things to the page is more important than an appearance of professionalism, which should come second. And yes it is a mnemonic, the rhyming helps in remembering what would otherwise be an arbitrary set of associations with numbers.Repapetilto (talk) 03:25, 22 September 2009 (UTC)

Personal mnemonics lack the notability guidelines of Wikipedia. You have to provide references that show that a mnemonic is in wide use. Wikipedia as an encyclopedia is not the right place for original research and ideas. You might want to check our sister project Wikiversity. Cacycle (talk) 03:47, 22 September 2009 (UTC)
Well alright, I still think that's misguided though. And I haven't yet used wikiversity but maybe I should begin checking that out.Repapetilto (talk) 03:59, 22 September 2009 (UTC)


It would be nice to know the serotonin affinities of the different receptors. Some information from here: Serotonin itself binds at most populations of 5-HT receptors with low nanomolar affinity
Icek (talk) 09:18, 20 August 2010 (UTC)

quetiapine = 5-HT1A agonist or antagonist?[edit]

This page lists quetiapine as a 5-HT1A agonist. However, the 5-HT1A page and the Quetiapine page list it as an antagonist for 5-HT1A. Which is correct? Rosemary9999 (talk) 01:13, 29 December 2010 (UTC)Rosemary

it should say that it is a partial agonist at the 5ht1a receptor.

source- Jensen NH, Rodriguiz RM, Caron MG, Wetsel WC, Rothman RB, Roth BL. N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine’s antidepressant activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33:2303-12.

Assessment comment - from 2007[edit]

The comment(s) below were originally left at Talk:5-HT receptor/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

More references needed throughout. -- MarcoTolo 01:27, 6 March 2007 (UTC)

Last edited at 01:27, 6 March 2007 (UTC). Substituted at 06:09, 29 April 2016 (UTC)

Potential article refs[edit]

Someone sent me these; I think they might be useful to add content from in this article. Seppi333 (Insert ) 00:11, 25 August 2016 (UTC)


  1. ^ Sanger GJ (November 2009). "Translating 5-HT4 receptor pharmacology". Neurogastroenterol. Motil. 21 (12): 1235–1238. doi:10.1111/j.1365-2982.2009.01425.x. PMID 19906028. 

Long lists have expanded the subtypes table - duplication[edit]

Probably the long lists of agonists and antagonists are repeated in the individual 5-HT receptor family articles (eg as in 5-HT6_receptor) so does it add enough value to repeat them here (with the extra cost of maintaining both) ? Similar lists in the Serotonergics template. - Rod57 (talk) 10:57, 30 September 2016 (UTC)

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