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- Pralidoxime and similar oxime acetylcholinesterase reactivators (the "golden standard" of these beeing now asoxime) are useful only in serious life-threating intoxications by some organophosphates (e.g. parathion, or NA's sarin or VX); they are less to not at all useful in soman (GD) intoxications, and actually contraindicated in carbamate intoxications (by carbaryl, carbofurane, bendiocarb or neostigmine), because, upon decarbamoylation of the blocked enzyme, oxime carbamates, that are more toxic than the actual parent noxae (i.e. the carabamate poison) forms; by "diezepan", I assume, you ment diazepam, which is indicated for symptomatic reversal of muscle fasciculations and seizures, as well as for calming the poisoned victim down and improve outcome in severe NCWA intoxications; noradrenaline is even of lower relevance, since it is only a symptomatic treatment of circulatory collapse, which is not a core symptom of AChEI intoxication; the only real "advisable" antidote for all AChEIs is atropine, given by i.v. titration. It is the only agent, that does help in all AChEI intoxications (though the most severe intoxications are often lethal despite high-dose atropine), regardless of their severity or casual noxis, i.e. one could not make a manifest AChEI intoxication worse by administration of atropine, as opposed to e.g. oximes. However, this article deals not so much with AChEI toxicology, it's only a brief summary of mechanisms and agents; the respective articles nerve agent and insecticide provide specific information about causal and symptomatic treatment of intoxications.--126.96.36.199 20:25, 29 September 2007 (UTC)
I was reading http://www.guardian.co.uk/science/2009/sep/20/neuroenhancers-us-brain-power-drugs and it mentioned cholinesterase inhibitors as a coming big thing in nootropics, but I was a little puzzled.
Choline supplements of various stripes have been available for a very long time, and I understood that they worked by encouraging choline->acetylcholine, and acetylcholinesterase works by destroying acetylcholine; so wouldn't the end-goal of choline supplementation and acetylcholinesterase inhibition be the same: a rise in acetylcholine? Why then the interest? --188.8.131.52 (talk) 21:33, 1 October 2009 (UTC)
Supplements inhibiting Acetylcholinesterase
Supplements inhibiting Acetylcholinesterase include
Such supplements, as well as Huperzine etc., share many of the side effects of pharmaceutical acetylcholinesterase inhibitors.