Talk:Adenosine receptor

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Question for someone out there with more knowledge than I: Are adenosine receptors concentrated in the brain, or are they distributed across the CNS? I'm actually wondering in terms of caffeine consumption in particular... it's just not clear to me whether the caffeine is binding to the adenosine receptors across the body or it it has to get to the brain before taking effect. Thanks. --AK7 12:48, 8 March 2006 (UTC)

  • It's my understanding that GPCRs in general (and adenosine receptors in particular) exist in cells and cell membranes throughout the body, not just the CNS. --ʀ6ʍɑʏ89 21:26, 8 March 2006 (UTC)

Adenosine A2B receptor[edit]

An additional subtype of the adenosine A2 receptor has been postulated, natobly the adenosine A2B receptor. — Preceding unsigned comment added by 81.49.254.6 (talkcontribs) 22:30, 14 July 2006 (UTC)

Adenosine A2A receptor[edit]

"and suppressing pacemaker cell function": If the effect is not to prevent the pacemaker function altogether, I think this would be clearer if the nature of the inhibition were more specifically indicated with another verb like 'depressing', 'preventing', re-shaping, or 'slowing'.
--Wikidity (talk) 23:12, 6 October 2014 (UTC)

Help![edit]

was just wondering does anyone know why adenosine binds to its receptors? what causes it? thank you 74cream 17:35, 20 November 2006 (UTC)

Major cleanup needed[edit]

This page needs a major clean up

  • "our observations raise the possibility that pharmacological blockade of A1 may have clinical utility" sounds like copy&paste from an scientific article our observations
  • "The A1 and A2a receptors of endogenous adenosine are believed to play a role in regulating myocardial oxygen consumption and coronary blood flow[1]" looks like copied, too. Otherwise, why is there a reference [1] at the end?
  • "The primary researchers, TJ Mader et al at Tufts University School of Medicine, have reported some promising results." also not good wiki style
  • Most of the 3 letter abbreviations lead to nothing
  • At least one the DOIs is wrong
  • for sure there is more.....

-- Panoramix303 18:00, 8 November 2007 (UTC)

I am just responding to the DOI comment. You are correct that the DOI to Mader, et al. was broken. This was due to the fact that the DOI as supplied by both the publisher and PubMed was incorrect and I download this DOI using User:Diberri's Wikipedia template filling tool from PubMed (Diberri's tool is fantastic by the way, highly recommended!). Therefore I have replaced the DOI with a direct http link. Cheers. Boghog2 20:11, 8 November 2007 (UTC)
As for the other points, Be bold!, don't be shy, step in and fix what you think needs to be fixed! Boghog2 20:11, 8 November 2007 (UTC)

I wish I had more time and knew about these receptors. I'd prefer someone working on it who knows more. -- Panoramix303 08:03, 9 November 2007 (UTC)

I started working on it. There is an article on the A1 receptor. Either we merge all adenosine receptors in one article (this one) or we make different entries for all of them and this page mainly refers to the single entries. Any suggestions?

-- Panoramix303 11:55, 9 November 2007 (UTC)

It is better to have an article for each receptor. The bot ProteinBoxBot aims to create a page for each notable gene in the human genome, and will help to provide content. ADORA1 (to be merged with A1 receptor) and ADORA2A (A2A receptor) are already here, and could benefit from wikilinks and additional informations. --Banus 13:52, 9 November 2007 (UTC)

The protein template was the easy part ;) Now I just have to add signaling, ligands and physiological role.... Give me some time. If you it is not done with in 1-2 weeks, remind me politely... -- Panoramix303 16:17, 9 November 2007 (UTC)

A1 inhibitory and excitory??[edit]

Also, the reference link to senselab is broken.--77.57.195.215 (talk) 17:38, 14 June 2015 (UTC)