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- 1 Surprising molecule?
- 2 technical comment repair recommendation
- 3 Maybe Dr. Nick Lane could write a section for non-microbiologists?
- 4 Over-verbosity?
- 5 ATP is not a molecule
- 6 Rewrite: ATP as energy currency
- 7 Rewrite: signalling section that was removed
- 8 A more detailed hydrolysis/condensation equation?
The first line of the article states that ATP is a "small but surprising molecule". I think it should be revised as molecules seldom are surprising, and if ATP for some reason is surprising then the reason for it being surprising should be stated. Also the sentence as it is currently formulated suggest that the molecule size is inversely related to the "surprisingness" of molecules. Suggestions: Either remove "surprising" or state why it is surprising. I don't have access to the cited article and cannot check whether this is taken from the article or added afterwards. — Preceding unsigned comment added by 188.8.131.52 (talk) 11:52, 29 August 2016 (UTC)
Overall, this article provides a very precise, detailed explanation of how ATP works within the cell, for organelles, and is used in biology. The article cites ATP as the "molecular unit of currency" in its opening, which is a very valuable depiction of what the compound is. This description helps to paint a vivid picture for how it is involved in cellular activities for those who are not yet familiar with the concept as well as how cells maintain their functions and the functions of their organelles over time. Because ATP's role is somewhat complex in explanation, the 4th paragraph in the opening section could explain what ATP does but not necessarily all of the terminology in its processes. An example of this is the lack of information in the article in regards to what cyclic AMP actually is. The article is rather technical in it's details, however, with basic knowledge of proteins, lipids, and cell function, the idea of how ATP works can be accurately described. This article would have been very helpful during micro biology as it would have helped to better illustrate ATP in terms of a method of preserving cellular function. This article would also have been helpful in describing the function of neurons. The last paragraph of the opening section gives somewhat of a history of ATP in the relative scientific history of biology. The rest of the article became very technical but was understandable with the aid of previous background in biology and chemistry. Glycolysis is mentioned, which is an important mention, and ties into the basic function of cell organelles as well as the Krebs Cycle. The entirety of the article overall addresses the various functions of ATP in aiding the various ongoings within the cell, which is a very good explanation for what ATP is and how it is important. The two questions about the content of cellular functions explained would be concerning the lack of mention of the terms "action potential" and "resting potential". Why were these terms specifically not included when explaining potential gradients? Would the article have made more sense to explicitly use and incorporate these terms when discussing electrical gradients?Mcclellan35 (talk) 04:09, 4 October 2016 (UTC)
technical comment repair recommendation
This article covers a quick in depth analysis of ATP fairly well. Most of the readers I assume are biochemistry and microbiology students attempting to get of sense of what ATP is. In order to provide information that can help guide the most common reader we should simplify the introduction, publish the thermochemistry (Enthalpy and Entropy), and change the graphic of the 3D model to the ideal image in the talk section above to match the 2D image above. The rest of the article is what I would expect in the ATP article. TerpeneOtto (talk) 03:03, 18 December 2016 (UTC)
Maybe Dr. Nick Lane could write a section for non-microbiologists?
I read The Vital Question by Nick Lane. I came away from the book thinking that ATP was super fascinating. I do not get that takeaway from this Wikipedia article. 184.108.40.206 (talk) 19:36, 7 July 2017 (UTC)
Why include the sentence "A system that is far from equilibrium contains Gibbs free energy, and is capable of doing work." I am not sure that this sentence is apposite here, adding to an overall "over-verbosity" that cutters a subject which of itself at its core, is complicated enough --let alone Gibb's free energy is to do with overall thermodynamic impetus for chemical reactions, not per se, if (say) a ball is going to roll down a hill.
ATP is not a molecule
The article and related ones often state or imply that ATP is a molecule. It is an anion. Always. The fully protonated form is instructive in some ways, but is awful to chemists who are picky about details like that. --Smokefoot (talk) 19:42, 2 September 2017 (UTC)
Rewrite: ATP as energy currency
A popular metaphor for people with an intuitive grip on energetics is to refer to ATP as "currency" and focus on exchanging energy from phosphodiester hydrolysis for endergonic processes, etc. For folks without this intuitive picture in their brains, the metaphor is probably confusing. Instead, the behavior of ATP can be described as a series of reactions, including the fact that it is recycled. So my plan is to mention the metaphor, but remove much of it from the article. --Smokefoot (talk) 14:13, 3 September 2017 (UTC)
Rewrite: signalling section that was removed
This section commented out below appears to be pretty specialized but maybe others can rescue parts for re-instatement. All adenosine receptors were shown to activate at least one subfamily of mitogen-activated protein kinases. The actions of adenosine are often antagonistic or synergistic to the actions of ATP. In the CNS, adenosine has multiple functions, such as modulation of neural development, neuron and glial signalling and the control of innate and adaptive immune systems.-->
A more detailed hydrolysis/condensation equation?
Currently the article contains the simple equation:
- ATP + H
2O → ADP + Pi
Do we reckon it's worth explicitly including the redox?
- ATP-4 + H2O → ADP-3 + Pi-2 + H+
- Good idea to be more explicit. There is no redox BTW.--Smokefoot (talk) 15:14, 17 September 2017 (UTC)