Talk:Antidepressant

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Exercise[edit]

Just dropping these refs here for now since I don't have time to add them here for another article for which I was doing this lit. search.

Refs+reflist

Not really surprising to me since it's also markedly anti-addictive too. Seppi333 (Insert  | Maintained) 06:40, 3 February 2015 (UTC)

References

  1. ^ Cooney GM, Dwan K, Greig CA, Lawlor DA, Rimer J, Waugh FR, et al. (2013). "Exercise for depression". Cochrane Database Syst Rev. 9: CD004366. doi:10.1002/14651858.CD004366.pub6. PMID 24026850. Authors’ conclusions
    Exercise is moderately more effective than a control intervention for reducing symptoms of depression, but analysis of methodologically robust trials only shows a smaller effect in favour of exercise. When compared to psychological or pharmacological therapies, exercise appears to be no more effective, though this conclusion is based on a few small trials.
     
  2. ^ Mura G, Moro MF, Patten SB, Carta MG (2014). "Exercise as an add-on strategy for the treatment of major depressive disorder: a systematic review". CNS Spectr. 19 (6): 496–508. doi:10.1017/S1092852913000953. PMID 24589012. Considered overall, the studies included in the present review showed a strong effectiveness of exercise combined with antidepressants. ...
    Conclusions
    This is the first review to have focused on exercise as an add-on strategy in the treatment of MDD. Our findings corroborate some previous observations that were based on few studies and which were difficult to generalize.41,51,73,92,93 Given the results of the present article, it seems that exercise might be an effective strategy to enhance the antidepressant effect of medication treatments. Moreover, we hypothesize that the main role of exercise on treatment-resistant depression is in inducing neurogenesis by increasing BDNF expression, as was demonstrated by several recent studies.
     
  3. ^ Josefsson T, Lindwall M, Archer T (2014). "Physical exercise intervention in depressive disorders: meta-analysis and systematic review". Scand J Med Sci Sports. 24 (2): 259–272. doi:10.1111/sms.12050. PMID 23362828. Physical activity has also become increasingly and firmly associated with improvements in mental health and psychological well-being (Mutrie, 2000; Landers & Arent, 2007). In particular, exercise is believed to be effective in preventing depression and also to significantly reduce depressive symptoms in clinical as well as in nonclinical populations (O’Neal et al., 2000; Landers & Arent, 2007). Several correlational studies show that exercise is negatively related to depressive symptoms (e.g., Galper et al., 2006; Hassmén et al., 2000). Moreover, a considerably large number of intervention studies have by now investigated the effect of various exercise programs on depression and the vast majority of them indicate that exercise significantly reduces depression (e.g., Blumenthal et al., 2007; Martinsen et al., 1985; Singh et al., 1997). 
  4. ^ Rosenbaum S, Tiedemann A, Sherrington C, Curtis J, Ward PB (2014). "Physical activity interventions for people with mental illness: a systematic review and meta-analysis". J Clin Psychiatry. 75 (9): 964–974. doi:10.4088/JCP.13r08765. PMID 24813261. Discussion
    This systematic review and meta-analysis found that physical activity reduced depressive symptoms among people with a psychiatric illness. The current meta-analysis differs from previous studies, as it included participants with depressive symptoms with a variety of psychiatric diagnoses (except dysthymia and eating disorders). ... This review provides strong evidence for the antidepressant effect of physical activity; however, the optimal exercise modality, volume, and intensity remain to be determined. ...
    Conclusion
    Few interventions exist whereby patients can hope to achieve improvements in both psychiatric symptoms and physical health simultaneously without significant risks of adverse effects. Physical activity offers substantial promise for improving outcomes for people living with mental illness, and the inclusion of physical activity and exercise programs within treatment facilities is warranted given the results of this review.
     

Will probably add something on its efficacy as a sole/adjunct treatment for depression under "Systematic reviews" using these 4 papers sometime tomorrow. Seppi333 (Insert  | Maintained) 04:53, 5 February 2015 (UTC)

Antidepressant[edit]

hi jeatdog (sorry for my english) yes my "source" was french.

http://apps.who.int/medicinedocs/fr/d/Js4896e/9.html "To avoid the association with dependence, an increasing number of researchers have used a different term, discontinuation syndrome, instead of withdrawal syndrome. The number of hits for discontinuation syndrome in searches of the international medical literature began to increase, relative to the occurrence of withdrawal syndrome, in 1997 after a symposium on antidepressant discontinuation syndrome held in 1996."

  • ok it is not written elli lily or pfizer. because it was a sentence i found in this version.

https://en.wikipedia.org/w/index.php?title=Physical_dependence&oldid=647840566 "SSRI drugs, which have an important use as antidepressants, are considered to cause physical dependence, although it is considered mild compared to drugs like opioids and GABA modulators, but they engender a discontinuation syndrome, which was originally called "SSRI withdrawal" until a 1997 symposium sponsored by Pfizer and Eli Lilly (the producers of several anti-depressants including Prozac and Effexor) was held, with the drug representative attendees concluding that "discontinuation syndrome" sounded less threatening than "withdrawal"

and steppi333 had revert this because no source. (and perhaps because the end of the sentence:"with the drug representative attendees concluding that "discontinuation syndrome" sounded less threatening than "withdrawal". i have a source, and i have revert the problematic end of the sentence. what the problem? Vatadoshu (talk) 20:41, 26 February 2015 (UTC)

Thanks for talking! sounds like you understand what was wrong with your initial edit - it was not true, was based on a french source, and bizarrely cited a diff of unsourced being removed from another article. Based on the WHO document it seems that you could write new and accurate content. please go ahead. Jytdog (talk) 21:34, 26 February 2015 (UTC)
@Jytdog: it is not my language. i can't reformulate, i will do spelling mistakes. please do it for me. it is not in my competence to write from zero just with a document. that's why i keep the english sentence.(i cited the diff unsourced because it correspond). (french source can be true). i don't know how to do a correct link. the wikicode is not the same than french wiki. i tried here and it is bad, really. perhaps you have bot that traduct the french wikicode link?. (this document is interesting, there are 31 pages,-the table of content is at the top of the document)Vatadoshu (talk) 09:52, 27 February 2015 (UTC)
I added the source as a reference. Jytdog (talk) 12:18, 27 February 2015 (UTC)
@Jytdog:
yep it's ok.
(i find the original source, it was that http://www.cochrane.dk/research/theses/Nielsen%20PhD.pdf that say"1996Authorities describe SSRI withdrawal reactions as rare and relatively mild.Closed symposium on “Antidepressant discontinuation events” sponsored by Eli Lilly.UK authorities published a review of SSRI withdrawal reactions with the conclusion that there was no evidence of a physical dependence problem with the SSRIs and that withdrawal reactions were rare and “relatively mild”A supplement to the Journal of Clinical Psychiatry was published with several proceedings from the symposium in 1996. The supplement was sponsored by Eli Lilly.1998At a meeting in the Committee on Safety of Medicines (UK) an Eli Lilly representative expressed concern of the use of the term “withdrawal reaction” when referring to the symptoms occurring on withdrawing treatment due to the fact that the term “withdrawal”has a specific meaning and implies that the drug is addictive. Lilly suggested the term “discontinuation reactions”."
->yep neither pfizer, neither "sounded less threatening than" , but the remaining was correct. just needed to be reformulate.).
the modification you made is ok for me.Vatadoshu (talk) 18:03, 27 February 2015 (UTC)

Autism in pregancy, reason for reverting[edit]

I am about to revert the addition of a subsection titled "Increase in autism risk" and would like to explain why. The first cited source is a primary research study and therefore not compatible with the guidelines in WP:MEDRS. Moreover there are serious reasons for doubting the validity of the conclusions, as the cited commentary explains. (By the way, it comes from Science magazine, not Science News as the citation states.) We should not use this material until it can be referenced to reputable secondary sources. Currently the only secondary source is the Science commentary, which certainly does not back up the statements. Looie496 (talk) 14:29, 16 December 2015 (UTC)

  • I will keep an eye on this story, and perhaps introduce the material again with a secondary source.50.159.6.134 (talk) 03:45, 17 December 2015 (UTC)

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Why a 'Categories' section?[edit]

What is the point of including

Categories

… when the categories are also listed at the bottom of the page? —Tamfang (talk) 17:31, 27 September 2016 (UTC)