|WikiProject Physiology||(Rated Start-class, Mid-importance)|
|This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Assigned student editor(s): Immcarle6. Assigned peer reviews: Immcarle8.|
Is there somebody that know, if there is rules for whis sequences are presented by APCs? If yes, can he describe it to page of Antigen-presenting cell? Thanks. Bal.
As well, there are specialized cells in particular organs (e.g., microglia in the brain, Kupffer cells in the liver), derived from macrophages that are also effective APCs.
I deleted this this because microglia, Kupffer cells, histocytes, osteoclasts, etc are just specific names for macrophages found in particular locations, and it is redundunt to mention them again. —Preceding unsigned comment added by 188.8.131.52 (talk) 18:02, 16 July 2008 (UTC)
Line about B cells as APC doesn't make sense
The line reads: "B-cells, which expresses (as B cell receptor) and secretes a specific antibody, can internalize the antigen which bind to its BCR and present it incorporated to MHC II molecule, but are inefficient APC for most other antigens."
This line never states what type of antigen the B is picking up, so it's conclusion that it is not an effective APC for most other antigens is confusing. Can anyone clarify this? —Preceding unsigned comment added by Mizower (talk • contribs) 01:43, 16 October 2010 (UTC)
Macrophage somewhat implied to be a T-cell?
This text, in a bullet within the Professional APCs section, is unclear:
Macrophages, which are also CD4+ cells and are therefore susceptible to infection by HIV as well, since HIV invades immune cells through CD4+ receptor interactions.
I'm studying this, and from what I've read elsewhere, macrophages aren't "CD4+ cells", but cells with exhibit the CD4 complex on their cell membrane. Since T-Helper cells are often referred to as "CD4+ T Helper cells" (e.g., in the introduction to CD4), the text as it stands can be read to imply that a macrophage is a type of T-cell. I'm not far enough along in my studies to want to correct this myself, however. — Preceding unsigned comment added by 184.108.40.206 (talk) 07:28, 17 October 2014 (UTC)
- Antigen is internalized via endocytosis
- Antigen is digested and destroyed in the phagolysosome
- Antigen presenting cell(A.P.C):is cell that diplays foreign antigen complexed with Major histocompatibitity complexes (M.H.C) on their surfaces.08:34, 25 March 2015 (UTC)220.127.116.11 (talk)Cite error: There are
<ref>tags on this page without content in them (see the help page).
Updating and adding new sections to the page
I've been assigned to work on this page. I'm planning to add a few new sections and lots of new information. This is my bibliography as it stands right now; any questions or comments are welcome.  Immcarle6 (talk) 20:57, 2 February 2016 (UTC)
Here is a draft of a new lead section for this article. Comments and suggestions welcome: An antigen-presenting cell (APC) is a cell that displays antigen on its surface in order to interact with or activate immune cells. Professional antigen-presenting cells, including macrophages, B cells, and dendritic cells, use class II major histocompatibility complexes to perform this process, which is called antigen presentation. These cells internalize and process foreign antigen before displaying short peptides in MHC class II molecules. T helper cells can then interact with the peptide and MHC molecule using their T cell receptor (TCR). Only exogenous antigen can be displayed on MHC class II molecules.
Non-professional antigen presenting cells include almost all cell types in the body, and use an MHC class I molecule to display endogenous antigen on the cell membrane. These peptides originated within the cell itself, in contrast to the exogenous antigen displayed by professional APCs. Cytotoxic T cells are able to interact with endogenous antigen presented using an MHC class I molecule.
Antigen-presenting cells are vital for an effective adaptive immune response, as the functioning of both cytotoxic and helper T cells is dependent on APCs. Antigen presentation can contribute to immune responses against both intracellular and extracellular pathogens as well as defense against tumors. Some new therapies against cancer involve the creation of artificial APCs to prime the adaptive immune system to target malignant cells. Immcarle6 (talk) 01:38, 10 February 2016 (UTC)
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