Talk:Neutropenic enterocolitis

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Most doctors call this typhlitis or neutropenic enterocolitis, not caecitis.[edit]

Most doctors call this neutropenic enterocolitis or typhlitis, not caecitis.

66.167.95.147 (talk) 22:30, 14 March 2010 (UTC)

Typhlitis is the commonly accepted and used term[edit]

Typhlitis derives from the greek "typhlon," (Latin cecum).


In PubMed,

Typhlitis gets 302 hits.

An attempt to search for caecitis is redirected by PubMed to a search for typhlitis:

PubMed's Search Details for the "caecitis" search are: "typhlitis"[MeSH Terms] OR "typhlitis"[All Fields] OR "caecitis"[All Fields]

Note it is "typhlitis" that is the MeSH Term


Google hits Feb 4 2010:


148,000 Typhlitis

23,500 "neutropenic enterocolitis"

22,300 Caecitis

2,040 Typhlenteritis

66.167.95.147 (talk) 22:37, 14 March 2010 (UTC)

this article should be renamed Typhlitis[edit]

That's what doctors and everyone else calls it, by a rather large margin.

66.167.95.147 (talk) 22:38, 14 March 2010 (UTC)

.

Working rewrite for "cause" section, noting C. Difficile overgrowth from incautious antibiotic use.[edit]

Cause[edit]

The condition is usually caused by gram positive enteric commensal bacteria of the gut (gut flora).

Typhlitis affects immunocompromised patients, such as those undergoing chemotherapy,[1] patients with AIDS, kidney transplant patients, or the elderly[2]. Clostridium difficile is a species of Gram-positive bacteria that causes diarrhea and other intestinal disease when competing bacteria are wiped out by antibiotics or chemotherapy.

Treatment draft[edit]

Typhlitis is a medical emergency. It has a very poor prognosis and is often fatal unless promptly recognized and aggressively treated.[3] Successful treatment hinges on:

... 1) early diagnosis provided by a high index of suspicion and the use of CT scanning, 2) nonoperative treatment for uncomplicated cases, and 3) elective right hemicolectomy to prevent recurrence....
... The authors have found nonoperative treatment highly effective in patients who do not manifest signs of peritonitis, perforation, gastrointestinal hemorrhage, or clinical deterioration. Recurrent typhlitis was frequent after conservative therapy (recurrence rate, 67 percent), however. [4] ...


--Ocdnctx (talk) 18:55, 26 August 2012 (UTC)

does anyone have access to this review or the review it references (circa 2005)?[edit]

The review may provide valuable information:

This review will cover the recent literature pertaining to the pathogenesis, diagnosis, and management


Davila ML.

Neutropenic enterocolitis.

Curr Opin Gastroenterol. 2006 Jan;22(1):44-7.

Abstract

PURPOSE OF REVIEW:

This review will cover the recent literature pertaining to the pathogenesis, diagnosis, and management of patients with neutropenic enterocolitis.

RECENT FINDINGS:

Neutropenic enterocolitis, also referred to as typhlitis, is a life-threatening gastrointestinal complication of chemotherapy, most often associated with leukemia or lymphoma. Recently, a larger number of reports have been published of individuals presenting with this syndrome after being treated with newer chemotherapeutic agents for solid tumors such as non-small cell lung, ovarian, and peritoneal cancer, as well as following autologous stem cell transplantation. Recent studies have also better characterized computed tomographic and ultrasonographic features of this entity that can help differentiate neutropenic enterocolitis from other gastrointestinal complications. A newly published systematic analysis of the literature, which included 145 articles, defines appropriate diagnostic criteria and treatment recommendations.

SUMMARY:

Neutropenic enterocolitis is a serious, potentially lethal complication of anticancer therapy. The studies discussed in this review will help the practitioner make an appropriate, early diagnosis and implement a therapeutic program that would improve the outcome of these patients.

PMID 16319675

--Ocdnctx (talk) 19:01, 26 August 2012 (UTC)

  1. ^ Keidan, RD (1989). "Recurrent typhlitis. A disease resulting from aggressive chemotherapy". Dis Colon Rectum. 32(3): 206–9. PMID 2920627.  Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help);
  2. ^ Stoehr TM and Koslin DB. 2004. Typhlitis. emedicine.com.
  3. ^ Keidan, RD (1989). "Recurrent typhlitis. A disease resulting from aggressive chemotherapy". Dis Colon Rectum. 32(3): 206–9. PMID 2920627.  Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help);
  4. ^ Keidan, RD (1989). "Recurrent typhlitis. A disease resulting from aggressive chemotherapy". Dis Colon Rectum. 32(3): 206–9. PMID 2920627.  Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help);