|WikiProject Medicine / Hematology-oncology||(Rated Start-class, High-importance)|
This article has a long way to go
This has been compiled from very basic patient information, written on about the 9th grade level, and it doesn't even give inline sources. WP:MEDMOS says that we're not writing for patients (although patients do educate themselves about their disease from WP and that's one of our purposes).
Here is the equivalent section within the leukemia article in Japanese: http://ja.wikipedia.org/wiki/%E7%99%BD%E8%A1%80%E7%97%85#.E5.B0.8F.E5.85.90.E7.99.BD.E8.A1.80.E7.97.85 — Preceding unsigned comment added by 188.8.131.52 (talk) 00:01, 16 November 2013 (UTC)
- Here's the Google Translate version:
Childhood leukemia Epidemiology of childhood leukemia
Slightly less in Asia in Japan develop three to about 100,000 people a year leukemia in children in Europe and the United States 4 per 100,000 children per year [ 141 ] , [ 142 ] . In pediatric Japan are being treated in the pediatric children about 700-800 people a year develop leukemia [ Note 31] [ 141 ] . The incidence of childhood leukemia is about half the incidence of adult whole but slightly more in boys ( male to female ratio = 1.35 ) of it is the same as adult . The characteristic in children leukemia ( about 5% ) , are mostly acute leukemia chronic leukemia is small , acute lymphocytic leukemia and 80 % are (ALL). Percentage of myeloid is reversed : lymphocytic in children and adults (AML) because there are many acute myeloid leukemia in adults . AML is developed at any age in childhood leukemia , but the onset is often in boys 2-3 years in ALL . Features of childhood leukemia
60-80 percent healed acute lymphoblastic leukemia in children , it is prognosis is better than adult leukemia in childhood leukemia overall , the prognosis so good in the older children of 10 years of age or older and infants under 1 year of age no . Type of genetic mutation that caused the leukemia Although there are many , gene mutation type good prognosis often in children of 2-9 years different types of gene mutations are common by age infants under 1 year of age there is a tendency that the proportion of type of leukemia prognosis is better low age increases with the exception [ 143 ] . However , the fact remains that it is a serious disease to say what a good prognosis is often childhood leukemia . 20-25 percent (in which chromosome is increased to 50 or more ) high- diploid , TEL-AML1 fusion gene was observed in 15-20 % , chromosomal and genetic abnormalities in acute lymphoblastic leukemia in children of two prognosis is good leukemia by chromosomal and genetic abnormalities . Chromosomal and genetic abnormalities with poor prognosis (MLL-AF4 fusion gene BCR-ABL fusion gene (or Philadelphia chromosome Ph +),) is 5% , the middle group is a little less than 50% in reverse . In acute myeloid leukemia in children is a prognosis intermediate group 40-60 % are long-term survival , most healing [ 143 ] . (TEL-AML1 fusion gene or high diploid ) ALL types of good prognosis has many leukemia 2-4 year-old children account for the majority of childhood leukemia in the number of people , but it of older children is a few in the entire in the leukemia rate of ALL types of good prognosis less and less , ( not the same thing as worse than ALL of the adult but ) it is considered a high-risk leukemia leukemia over the age of 10 [ 144 ] . However , assessing the poor prognostic factor is important leukemia types of poor prognosis in leukemia of 2-4 year-old children because there Some of them . Leukemia of infants under 1 year of age is 5-10% of childhood leukemia , ALL with the MLL-AF4 fusion gene was observed in about half of nature is strong medical transplantation very bad ALL with the MLL-AF4 fusion gene has been recommended [ 143 ] . Treatment of childhood leukemia
I do the treatment of four-phase of remission induction therapy , sanctuary therapy , intensive therapy and maintenance therapy in the treatment of ALL in children . Aiming for remission in two drugs Bingurisuchin and prednisolone (trade name Oncovin ) in remission induction therapy . That leukemia cells infiltrate the central nervous Many in ALL, such as cranial irradiation is carried out and a large dose of intrathecal methotrexate , in some cases as a sanctuary therapy for the treatment or prevention of central nervous system leukemia . Is performed cytarabine and polypharmacy and ( km side ) large doses in the intensive therapy aimed at eradication of leukemia cells remaining , and oral methotrexate and 6-MP as maintenance therapy in order to keep the leukemia cells that could survive any chance I continue for about 1-2 years . When you have got any chance or recurrence type and poor prognosis to examine the medical transplantation and [ 143 ] . Donor is easy to obtain compared to adult hematopoietic stem cells of a sufficient number can be obtained for transplantation in the bone marrow of petite women and umbilical cord blood low number of cells the body is small in children . Performance is not as good as ALL the treatment of AML in children , but using the anthracycline anticancer agent ( km side ) cytarabine , induction aims to complete remission with intensive therapy and maintenance therapy . Central nervous system leukemia less so in AML doing intrathecal anti-cancer agents prophylactic low [ 143 ] . In addition, the drugs listed above is an anti- cancer agent other than prednisolone . Down syndrome childhood leukemia
That it blood abnormalities variety occurs often in children with Down syndrome are known , leukemia also shows the incidence of 15 times the non- Down syndrome children . It presents a state similar to leukemia temporarily often in neonates with Down syndrome . Most of them heal spontaneously in a few months , but the child with Down's syndrome Some develop (AML-M7) acute megakaryoblastic leukemia . That become (AML-M7) acute megakaryoblastic leukemia in children with Down syndrome under the age of 3 large specifically compared to non- down children . The down children under 3 years later incidence rate trend is also the same as the non- Down syndrome children and [ 145 ] .