|WikiProject Molecular and Cell Biology||(Rated Start-class, Mid-importance)|
Concerning merge from acetylcholinesterase: I consciously merged the articles in the reverse direction because acetylcholinesterase is fully dealt with on this page. Moreover, as the current page mentions there are two enzymes referred to as cholinesterase. It would thus be erroneous or misleading at least to redirect cholinesterase to the other article. Notice I left the stub status there. --Phils 17:05, 18 Oct 2004 (UTC)
Removed here, if someone could find the documents in question without page forwarding links, it'd be awesome. Otherwise will do later hopefully.
Cholinesterase inhibitor discoverer
Revision as of 06:38, 22 August 2005 by 220.127.116.11 stated that
Cholinesterase inhibitors were discovered by Professor Cardillo of Sydney University, Australia.
On August 23rd 2005, User:Jfdwolff removed that part and commented:
Strychnine has been around for much longer
Although I'm unable to confirm the first statement, I know for sure that the counterargument doesn't stand. Even though the manifestations of a strychnine poisoning resemble that of a cholinesterase inhibitor massive overdose in that both may produce myoclonic or tetanic convulsion, strychnine is not a cholinesterase inhibitor.
Strychnine works by blocking the release of glycine from inhibitory interneurons in the spinal cord. This increases reflex excitability and result in convulsion.
If someone can ascertain that a Professor Cardillo did discover cholinesterase inhibitor, please add it to the text and state your source.
Benoitduhaime 05:24, 9 October 2005 (UTC)
Please do not assign a EC number, examplified in the article, to a class of the enzymes
Question Relating to All Topics Related to Acetylcholinesterase
it seems as though the question of WHY organophosphates inhibit this enzyme is skimmed, skipped, or glossed over (probably intentionally so)... It seems as though no authors are willing to say something as clear cut as: "the organophosphate inhibitors structurally resemble the activated tetrahedral transition state of enzyme bound acetylcholine, and inclusion of a leaving group that is labile upon reaction of the phosphorous center with the the serine residue results in an irreversibly deactivated enzyme" I have brought this up because this specific example is often used in introductory upper division biochemistry courses to help teach students about host-guest macromolecular chemistry, common enzymatic mechanisms (carbonyl-->tetrahedral Tstate stabilized by His residues for example), etc... Yet I see no mention of this, even with a big "warning" or "disclaimer" that says: "this information is not general, and not all classes of inhibitors function in this way"18.104.22.168 (talk) 21:09, 9 February 2011 (UTC)
Pop culture is silly
The discussion of cholinesterase in pop culture is pretty worthless. Who cares if the word was used in a song title or some random TV show? It's not noteworthy. — Preceding unsigned comment added by 22.214.171.124 (talk) 16:48, 6 January 2017 (UTC)
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