|WikiProject Molecular and Cell Biology||(Rated B-class, High-importance)|
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I have some serious complaints about the picture attached to this article. (http://en.wikipedia.org/wiki/Image:Cytoplasmic_dynein.PNG)
According to the text, the Stalk binds the head with the Microtubule. But the picture looks like such contact is only incidental and temporary.
The caption text seems to explain the picture, but it should be rephprased to make it Undertandable, not merely Readable.
Further, if the "heads" "walk" along the Microtuble, then what is the Cargo?
So this seems read, rephrased, and written by somebody entirely unfamiliar with the issue.
- Maybe the figure needs to be turned into an animated gif that would show the movement. --JWSchmidt 22:19, 27 December 2005 (UTC)
- Sure, I support finding a better picture or animation. I made this one because I couldn't find a public domain one. I think the confusion about the globular "heads" walking along the microtubule has to do with the fact that the heads more resemble feet! The cargo, for example vessicles or other cellular products, is bound to the opposite end, where you'd expect a head to be.
- I'm not sure I understand your concern about the stalk binding the heads, perhaps you could explain more?
I agree that the picture is badly drawn/made and does not clearly illustrate the correct function of dynein arms. It appears that it has been on mspaint. —Preceding unsigned comment added by Simmu1992 (talk • contribs) 07:21, 4 November 2008 (UTC)
Stall force, step size, ...
I am missing numbers: What is the stall of a single dynein?
Schmitz, Holocomb-Wygle, ... Lindemann, Biophys. J.,2000 measure 10 pN
What is the step size? 8 nm such as kinesin?
If so, each dynein could do 80 pN nm of work for each ATP (which provides 100 pN nm of energy upon hydrolysation). This would be a remarkable efficiency.
I like the way this article is written. Comprehensive, yet also explained directly so that non-experts can understand it. Not enough WP science articles are written so clearly. Bravo to the editors! Davemcarlson (talk) 08:11, 17 March 2013 (UTC)