Talk:Ecological study

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Ecological studies are studies of risk-modifying factors on health or other outcomes based on populations defined either geographically or temporally. Both risk-modifying factors and outcomes are averaged for the populations in each geographical or temporal unit and then compared using standard statistical methods.

Ecological studies have often found links between risk-modifying factors and health outcomes well in advance of other epidemiological or laboratory approaches. Several examples are given here.

The study by John Snow regarding a cholera outbreak in London is considered the first ecological study to solve a health issue. He used a map of deaths from cholera to determine that the source of the cholera was a pump on Broad Street. He had the pump handle removed in 1854 and people stopped dying there [Newsom, 2006]. It was only when Koch discovered bacteria years later that the mechanism of cholera transmission was understood [Kaufmann, 2005].

Dietary risk factors for cancer have also been studied using both geographical and temporal ecological studies. Multi-country ecological studies of cancer incidence and mortality rates with respect to national diets have shown that some dietary factors such as animal products (meat, milk, fish and eggs), added sweeteners/sugar, and some fats appear to be risk factors for many types of cancer, while cereals/grains and vegetable products as a whole appear to be risk reduction factors for many types of cancer [Armstrong, 1975; Grant, 2014]. Temporal changes in Japan in the types of cancer common in Western developed countries have been linked to the nutrition transition to the Western diet [Tominaga S, Kuroishi, 1997].

An important advancement in the understanding of risk-modifying factors for cancer was made by examining maps of cancer mortality rates. The map of colon cancer mortality rates in the United States was used by the brothers Cedric and Frank Garland to propose the hypothesis that solar ultraviolet B (UVB) radiation, through vitamin D production, reduced the risk of cancer (the UVB-vitamin D-cancer hypothesis) [Garland, 1980]. Since then many ecological studies have been performed relating the reduction of incidence or mortality rates of over 20 types of cancer to lower solar UVB doses [Moukayed, 2013].

Links between diet and Alzheimer’s disease have been studied using both geographical and temporal ecological studies. The first paper linking diet to risk of Alzheimer’s disease was a multicountry ecological study published in 1997 [Grant, 2007]. It used prevalence of Alzheimer’s disease in 11 countries along with dietary supply factors, finding that total fat and total energy (caloric) supply were strongly correlated with prevalence, while fish and cereals/grains were inversely correlated (i.e., protective). Diet is now considered an important risk-modifying factor for Alzheimer’s disease [Devanand, 2013]. Recently it was reported that the rapid risk of Alzheimer’s disease in Japan between 1985 and 2007 was likely due to the nutrition transition from the traditional Japanese diet to the Western diet [Grant, 2013].

Another example of the use of temporal ecological studies relates to influenza. John Cannell and associates hypothesized that the seasonality of influenza was largely driven by seasonal variations in solar UVB doses and calcidiol levels [Cannell, 2006]. A randomized controlled trial involving Japanese school children found that taking 1000 IU per day vitamin D3 reduced the risk of type A influenza by two-thirds [Urashima, 2010].

Ecological studies are particularly useful for generating hypotheses since they can use existing data sets and rapidly test the hypothesis. The advantages of the ecological studies include the large number of people that can be included in the study and the large number of risk-modifying factors that can be examined.

The term “ecological fallacy” means that the findings for the groups may not apply to individuals in the group. However, this term also applies to observational studies and randomized controlled trials. All epidemiological studies include some people who have health outcomes related to the risk-modifying factors studied and some who do not. For example, genetic differences affect how people respond to pharmaceutical drugs. Thus, concern about the ecological fallacy should not be used to disparage ecological studies. The more important consideration is that ecological studies should include as many known risk-modifying factors for any outcome as possible, adding others if warranted. Then the results should be evaluated by other methods, using, for example, Hill’s criteria for causality in a biological system.

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References:

Armstrong B, Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975 Apr 15;15(4):617-31.

Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E. Epidemic influenza and vitamin D. Epidemiol Infect. 2006 Dec;134(6):1129-40.

Devanand D, Lee J, Luchsinger J, Manly J, Marder K, Mayeux R, Scarmeas N, Schupf N, Stern Y. Lessons from epidemiologic research about risk factors, modifiers, and progression of late onset Alzheimer's Disease in New York City at Columbia University Medical Center. J Alzheimers Dis. 2013;33 Suppl 1:S447-55.

Grant WB. A multicountry ecological study of cancer incidence rates in 2008 with respect to various risk-modifying factors, Nutrients. 2014;6(1):163-189. http://www.mdpi.com/2072-6643/6/1/163 Grant WB. Trends in diet and Alzheimer’s disease during the nutrition transition in Japan and developing countries. J Alz Dis, 2014 Jan 1;38(3):611-20.

Kaufmann SH, Schaible UE. 100th anniversary of Robert Koch's Nobel Prize for the discovery of the tubercle bacillus. Trends Microbiol. 2005 Oct;13(10):469-75.

Moukayed M, Grant WB. Molecular link between vitamin D and cancer prevention. Nutrients. 2013;5(10):3993-4023.

Newsom SW. Pioneers in infection control: John Snow, Henry Whitehead, the Broad Street pump, and the beginnings of geographical epidemiology. J Hosp Infect. 2006 Nov;64(3):210-6.

Tominaga S, Kuroishi T. An ecological study on diet/nutrition and cancer in Japan. Int J Cancer. 1997;Suppl 10:2-6.

Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010 May;91(5):1255-60.

Jag8452 (talk) 21:36, 25 January 2014 (UTC)