Talk:Ethinylestradiol

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No space in title?[edit]

Why is the title of the article all one word, but in the article itself the name is always broken apart into two words? Shouldn't it be consistent either way? Lyrl 12:14, 3 July 2006 (UTC)

It is generally written in 2 words: Ethinyl estradiol. Ekem 14:45, 5 July 2006 (UTC)

Someone recently moved it because INN (not sure what that is) spells it as one word, and wikipedia apparently encourages INN spellings (Wikipedia:Naming conventions (chemistry)). I do prefer two words, though. Lyrl 22:16, 5 July 2006 (UTC)

Copyright Violations removed[edit]

I have just removed several sections from the article for being blatant unedited copyright violations, taken straight from this page. I find it rather sad that such an important drug is so poorly documented here on wikipedia that someone could get away with copyvios. Hopefully we can start to give this article the love it deserves :) LinaMishima (talk) 23:25, 28 March 2009 (UTC)

Title versus name in lemma[edit]

The title names the compound with an "i" following the "h". As the name of the substituent is derived from Ethyne (the systematic name of acetylene), then name of this lemma should be "Ethynylestradiol", as in the first line. Is this lemme to be renamed again? T.vanschaik (talk) 10:12, 18 August 2010 (UTC)

One would think, given the IUPAC rules. In this case however, the trade name is in fact "ethinyl estradiol". Must have been named by a pharmacologist :oD. - Puddin'head24.9.79.14 (talk) 01:00, 13 March 2015 (UTC)

Ethynilestradiol potency vs. 17-ß Estradiol[edit]

I agree that very few informations are (freely) available all around about this very common and widely used hormon, and as a consequence also Wikipedia currently offers very little about it. In particular, one topic of interest would be explaining/understanding the relative potency of EE versus plain Estradiol in binding to E receptors and activating them. EE appears ways more potent (why ?), since oral formulations always include EE in microgram dosages, while E (micronized or valerate) is always dosed in milligrams. Any interested people would like to understand that by reading this entry. — Preceding unsigned comment added by 87.4.120.199 (talk) 19:37, 10 March 2014 (UTC)

The greater potency of EE is generally considered to be a pharmacokinetic effect - it is not oxidized at the 17 position due to the addition of the ethyne group and thus is not cleared as rapidly. I have not seen any information on the Kd value of EE, nor a comparison of receptor binding to that of estradiol. Will take a look to see if I can find anything. - Puddin'head207.93.211.50 (talk) 17:35, 10 March 2015 (UTC)

Bioavailability reported as "97% bound"[edit]

The article conflates bioavailability with protein binding in the boxes below the chemical structure. Should an entry for "protein binding" be added, or should the proper bioavailability data simply be inserted in place of what is currently there? - Puddin'head207.93.211.50 (talk) 17:39, 10 March 2015 (UTC)

Trans Health?[edit]

Why does this article contain zero info about the use of EE in trans health? Can anybody add anything? — Preceding unsigned comment added by Funkendub (talkcontribs) 19:58, 23 August 2017 (UTC)

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Still the main player?[edit]

Article says

EE is used as a medication and is a component of almost all formulations of combined oral contraceptive (COC) pills, being nearly the exclusive estrogen used for this purpose.

But ref is from 1999. Has this changed since? 193.167.228.180 (talk) 11:38, 3 October 2017 (UTC)

Revising Wikipedia Assignment: Ethinylestradiol[edit]

As part of an elective class, a group of four of us will be editing this article over the course of the next 5 weeks. Sections have been assigned to particular team members within our group (Hbary, Kristran, Ucla.cesar).

Our timeline is as follows:

  • 10/18/17 – Choose sections of Ethinylestradiol page to edit and summarize article improvement goals (done, see below)
  • 10/30/17 – Post preliminary edits to page and prepare them for peer review
  • 11/08/17 – Complete peer review, then examine peer review results and revise submission
  • 11/15/17 – Submit final edits to page

Medical Uses (Hbary)

  • Verify sources in this section to see if they are up to date
  • Add possible transgender hormonal use (brought up in talk page)
  • Maybe add about emergency contraception? (ex: taking 2 ethinylestradiol pills)

Contraindications (Kandyskim)

  • Expand on contraindications specific for EE
  • Add EE and pregnancy considerations
  • Add EE and breast-feeding considerations
  • Expand on contraindications for COCs containing EE using CDC’s Summary Chart of U.S. Medical Eligibility Criteria for Contraceptive Use updated in 2017

Side effects (Ucla.cesar)

  • I plan to compare this section with the therapeutics class notes, in order to make sure the information is up to date. Additionally, I plan to look up the incidence rate of these side effects, in order to provide a better understanding of the medication. I will check FDA updates regarding ethinylestradiol rare reactions, such as venous thromboembolism, cholestatic hepatotoxicity, and endometrial cancer. I will potentially add side effects that are not included in the article or should be expanded on based on current guidelines.

Interactions (Kristran)

  • Provide more complete range of interactions using reliable sources
  • Check/verify citations and sources

Kandyskim (talk) 18:56, 12 October 2017 (UTC)

Thanks for providing notice. Please make sure the sources comply with WP:MEDR and please keep the overall WP:WEIGHT of sections sensible with regard to the rest of the article. Jytdog (talk) 06:40, 13 October 2017 (UTC)