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Many of the drugs cites are actually used to treat psychosis etc. except loratadine (= claritine) and fexofenadine (=telfast which I added). Are there no other antihistamines in the classical sense, treating allergies? Sikkema (talk) 20:08, 1 June 2008 (UTC)

Yes, of course; they're listed at H1 antagonist. Fvasconcellos (t·c) 22:30, 1 June 2008 (UTC)


This is a very complicated article, that the average person researching would have no idea. It would be nice to have things explained a bit more in laymans terms. —Preceding unsigned comment added by (talk) 06:34, 31 July 2008 (UTC)

I absolutely agree with the above contribution. Is there any chance a friendly editor could have a go at rewriting this for the layperson? (talk) 23:50, 9 February 2009 (UTC)

the use of epipens? —Preceding unsigned comment added by (talk) 10:16, 2 January 2009 (UTC)

This article has very little information about Histamine Antagonists. Future authors should review the article about Aspirin for a good example. It contains details about the action of the drugs, has a history section, a therapeutic uses section, a mechanism of action section, a chemistry section, an adverse effects section and a few more. I would like to see the Histamine antagonist article include a lot more information about this class of drugs. —Preceding unsigned comment added by (talk) 20:19, 12 October 2009 (UTC)

Yes, please some context for those who are not specialists of this topic. I came to this article looking for information on the history and development of antihistamines, and there is no background information given. Janice Vian, Ph.D. (talk) 21:57, 12 February 2012 (UTC)

A historical overview would be useful. When were antihistamines first tried and introduced? Presentations (sprays, capsules, tablets) The list of antihistamines is helpful, but what about dividing it into 1st generation and second generation antihistamines. Everybody got to be somewhere! (talk) 00:20, 5 January 2013 (UTC)

It has now been six years since the initial comment in this section asking for a less-technical explanation of what antihistamines are, and so far nothing has been done about it. I am going to take this as encouragement to rewrite the intro, at least, and put it in terms that are much less technical and less medical, saving that stuff for later on in the piece. If anyone decides to undo this action, please make sure you read this talk page entry first and justify your actions. Thanks. KDS4444Talk 19:15, 31 January 2015 (UTC)

Vitamin C[edit]

"Large doses of vitamin C are known to alleviate shock by inhibiting deaminizing proteins that release histamine.[4]" Source: I question this (and just removed it), as the only source listed smells of a lone kook, though maybe there's a body of research supporting this I'm unaware of. I suggest if it goes back in that stronger sources be used. (talk) 02:26, 18 October 2011 (UTC)

Do antihistamines lose effectiveness as sleep regulators over time?[edit]

Does anybody know? I'd like such information to be part of the article. I think it's a fair guess that they do, since receptors usually increase or decrease in amount to compensate for artificial intervention. But I don't know. Again, would like to. Firrtree (talk) 06:36, 1 November 2012 (UTC)