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mental disorder?[edit]

I came here assuming this is a term widely used to describe a form of mental disorder, but can't find anything relating to it. Is that because it's not an "official term"? Thanks. (talk) —Preceding undated comment added 20:13, 20 June 2010 (UTC).

Type 5?[edit]

i was to believe that an immune response that targetted the bodies own tissues was an autoimmune disease, not neccesarily a hypersensitivity reaction. perhaps it should be clearer what the relationship between the two are? —Preceding unsigned comment added by Chaotic rach (talkcontribs)

  • Would you please cite the text that is confusing?Niels Olson 00:45, 19 April 2007 (UTC)
It's the strange Type 5 text. The questioner is right: Myasthenia gravis and Graves Disease are B-cell mediated autoimmune diseases. An "allergy" (as the term is used by the average person) requires a non-self component for the antigen. WhatamIdoing 01:39, 7 June 2007 (UTC)
Unfortunately, the colloquial use of allergy simplifies a more complex immunological reality. An "allergy" to peanuts, for instance, is mediated by a Type I hypersensitivity mechanism, whereas an "allergy" to nickel (for example in less expensive jewelry) is a delayed-type hypersensitivity (type IV). To answer the original questioner, these hypersensitivity reactions are the mechanisms by which some autoimmune diseases cause damage. In Myasthenia gravis and Graves Disease, antibodies are produced to the acetylcholine receptor and the thyroid stimulating hormone receptor respectively. Unlike most Type II hypersensitivities, these diseases don't cause the death of the cells, rather depletion of the receptor (in MG) or activation of the receptor (in Graves). Thus, they are sometimes classified as type V, to acknowledge the fact that they do not cause the death of cells via ADCC. This being the case, can you suggest any changes that might help to clarify the article? Jprawn 20:34, 9 June 2007 (UTC)

I just changed the mediator for V from T cells to IgM/IgG (complement), as from what I can tell, that's what it should be. —Preceding unsigned comment added by (talk) 00:19, 13 August 2009 (UTC)

A Hypersensitivity reaction is any harmfull inapropriate response of the immune system, the article is correct type 5 is receptor mediated as both diseases stated attack the recepters, Autoimmune disease is a wide array of diseases and falls in many types of Hypersensitivities not just type 5, eg: Autoimmune diabettes is CD 4 mediated and is Hypersensitivity type 4, lupus is IgG and IgM mediated wich forms immune complexes (type3) but good pastures disease and primary billary Cirrhosis are also IgG and IgM mediated but only attack the tissue directly and do not form complexes and do not deposit (type 2). myesthemia and graves only attack receptors and would be classified under type 5. — Preceding unsigned comment added by (talk) 20:43, 18 February 2012 (UTC)

Is farmer's lung really a type II hypersensitivity?[edit]

It was my understanding that farmer's lung (hypersensitivity pneumonitis) was classically thought to be a type III hypersensitivity, although more recent research (Allergy Asthma Proc. 2007 Jan-Feb;28(1):25-7) has shown type IV hypersensitivity as having an important role. Should the link to farmer's lung be moved down to either type III or type IV? Jprawn 19:16, 17 May 2007 (UTC)

type 2 cytotoxic vs noncytotoxic[edit]

I thought there is a distinction btwn type 2 cytotoxic and noncytotoxic. Please confirm. —Preceding unsigned comment added by Tkjazzer (talkcontribs) 20:55, 11 November 2007 (UTC)

Type 3 - immune complex[edit]

Shouldn't Fibromyaliga be listed under this type? I know there is still a lot that is unknown about Fibromyalgia, but it seems this would be the appropriate category to list it as it does cause hypersensitivity to temperature and touch. Angelmunchkin04 (talk) 19:05, 22 January 2008 (UTC)

Type V reference[edit]

In the article (Rajan TV (July 2003)) granuloma was described as type V hypersensitivity! Nothing about autoimmune reactions! Could anybody refer some adequate article, please?! —Preceding unsigned comment added by (talk) 00:41, 23 February 2011 (UTC)

Hypersensitivity type VI  ??[edit]

Im an intern Immunotechnologist and during my studies I have heard that they have created a Hypersensitivity type VI group.
still being a delayed T-cell dissorder but specificaly with CD-8 and NK cells removing them from Hypersensitivity type IV group.
This would specificaly effect; a poison ivy contact dermatitis as it is a CD8 regulated respons as the lipid component is presented by MHC 1
(contact dermatitis' regulated by CD4 would still be Hypersensitivity type IV) but as well as tissue transplant 
rejections due to tissue type as it is regulated by NK and CD8 cells  

(due to blood group would be Hypersensitivity type II, and chronic would be Hypersensitivity IV due to CD4 action).

Is this completely false or is it true, and can you recomend any relivant articles?
and if it is true is this page not out dated.

(and as far as I know farmers lung is a Hypersensitivity type III, but can move into a chronic phase forming Granulomas and becoming a Hypersensitivity type IV, not a type II as this disease is mediated by IgG and IgM not IgE)

If i want to remain only with th imunity and hence want abstain medicine its possible for me but am needing a very good ness of a will power . I am needing to keep a good contact with immunity which i am born with . Thus i could keep th metabolism not needing to urge for activity . ...... In case someone other than my own self reads this then i humbly request to consider th fact that i am not a man of medicine rather its just common-sense about some facts which my self got confirmed by my personal experience . So i may using this rest fullness of metabolism in sense other than it stays in its own particular ...... Whatever . Thatsit . Here by me . I have created this page basically for my own reasoning . — Preceding unsigned comment added by 99sad (talkcontribs) 18:17, 3 November 2012 (UTC)

This article is probably very outdated[edit]

The Coombs and Gell classification is from 1963. There has been a LOT of new research, for example food reactions mediated by immunoglobulin free light chains and innate immune reactions to gluten.

I'm thinking there is a need for a Food Hypersensitivity article. "Food hypersensitivity" is an umbrella term for adverse reactions to food, whether immune reactions or non-immune reactions. Food hypersensitivity includes "food intolerance", i.e. food reactions that do not involve the immune system - and immune reactions to food, which include innate immune responses, acquired IgE reactions to food and acquired non-IgE reactions to food.Puffysphere (talk) 13:17, 25 June 2013 (UTC)

You need to provide high-quality secondary sources (e.g., not original publications from medical experiments, but perhaps review articles or medical textbooks) that support this significant change in definition. WhatamIdoing (talk) 08:56, 26 June 2013 (UTC)
I changed my mind - "food hypersensitivity" is a good umbrella term for adverse immune reactions to food, given this article.
There's a Wikipedia article Adverse food reaction which is a good umbrella term for ALL kinds of food reactions. That article could have links to articles on the various kinds of food reactions.
This article (Hypersensitivity) could be modified to include info on Ig free light chains, gluten sensitivity via innate immunity, etc. These reactions don't seem to fit in the old Gell-Coombs classification, though.Puffysphere (talk) 20:07, 26 June 2013 (UTC)
ps I tried to find out about the "egg white intolerance" you talk about. That is probably actually a kind of allergy, not a "pseudoallergy". Egg whites have potent allergens, and if a protein in eggwhites can trigger the release of histamine from mast cells, that is probably through an antibody mechanism.
Some foods like strawberries have a lot of histamine, and that can trigger what's called a pseudoallergic reaction. But eggwhites don't have a lot of histamine so far as I know.
I think the "egg white intolerance" is probably just one kind of non-IgE mediated allergy, similar to soy, milk, wheat, etc. non-IgE mediated allergies. I haven't seen anything online indicating otherwise.Puffysphere (talk) 20:21, 26 June 2013 (UTC)
"Non-IgE-mediated" means "not a true allergy". You can be sensitive/intolerant, but the formal definition requires IgE mediation.
Not true - as I said, people have found non-IgE mechanisms, and I gave you sources for the current definition of allergy, which does NOT require it be IgE-mediated. What I gave you IS the formal definition. You're expressing an outdated point of view. Puffysphere (talk) 00:30, 7 July 2013 (UTC)
Egg white intolerance works almost like strawberries, except that instead of containing histamine, they chemically trigger (by direct contact) histamine release from mast cells. This is a pharmacological reaction, and it is not considered a true allergy. (You can also have a true allergy to egg whites, but that involves IgE antibodies.) WhatamIdoing (talk) 07:09, 27 June 2013 (UTC)
There is actually very little evidence for "egg white intolerance" and foods somehow chemically triggering histamine release.
And, as I said, it is likely enough that these reactions do occur via the immune system, they just aren't classical IgE-mediated allergies. I saw nothing to exclude this, and I did poke around some on Medline. Puffysphere (talk) 00:30, 7 July 2013 (UTC)

Additional Citations Needed[edit]

I have added the medref template to this article. There was a bit of an edit war going on the main page of this article and I have removed those comments from the main page. Those discussions should occur on the talk page and should never make their way to the articles main page.

For such a fundamental concept in immunological research it is completely unacceptable that this article only has ~6 references of which 3 are text book references and none of the research references are newer than 2003. This article requires considerably more research literature referencing whether that is from research or review articles in the literature. For the editor that added Tau et al.: that is a text book citation and thus does not alone meet the burden of evidence to full support your statements. –TheIguana (talk) 18:14, 28 September 2013 (UTC)reeee