Talk:Hypothyroidism

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Moved here[edit]

"In a retrospective analysis of a sample of 62 mother with hypothyroidism and children compared to a control of 124 participants it was found that untreated mothers (48 participants) had children that scored 7 points lower than the control and 19% had IQ's lower than 85 points, Treated mothers (14 participants) children had IQ's similar to the control, the controls average IQ score of 107 and 5% occurrence of IQ scores below 85 points.[1]"

"Syncope caused by complete AV block due to severe hypothyroidism leading to extreme bradycardia has been recorded as successfully being treated with levothyroxine, AV conduction was restored not requiring internal implantation of a pacemaker.

[2]"

Need better sources for this type of content. Doc James (talk · contribs · email) 18:02, 16 April 2017 (UTC)

Historical Methods of Diagnosis?[edit]

Is there any information out there on how hypothyroidism was diagnosed and treated before the modern tests existed? I've heard from one source that up to the early 1980s it was often diagnosed by symptoms, and then slowly increasing doses of levothyroxine were used until symptoms of induced hyperthyroidism showed up at which point the dose was decreased by 10% and that was used. 207.172.210.101 (talk) 04:54, 16 May 2017 (UTC)

That is distinctly possible but I haven't found a good historical source that compares previous to current practice. The radioimmunoassays of the thyroid hormones and TSH have substantially improved diagnosis. JFW | T@lk 13:45, 16 May 2017 (UTC)
I found this source. However it does not mention the treatment regime that you [IP editor] describe. Axl ¤ [Talk] 14:55, 16 May 2017 (UTC)

Hepatic Invovlement needs Including.[edit]

The article at present does not address issues with peripheral converstion of Thyroxine to Triiodothyronine. This occuring primarily at the liver. Under conversion of T4 to T3 is addressed in at least one of [3]The Oxford textbook of diabetes endocrinology or The Williams [4]. While much rarer these are also a cause of hypothyroidism.

More recent research has implicated both Cortisol and Inflammation in this issue, I will attempt to find references when time permits. Leopardtail (talk) 18:28, 23 May 2017 (UTC)

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Lancet[edit]

Seminar doi:10.1016/S0140-6736(17)30703-1 JFW | T@lk 11:33, 24 September 2017 (UTC)

BTA has also made this: persistent symptoms despite normal TSH doi:10.1111/cen.12824 JFW | T@lk 11:39, 24 September 2017 (UTC)

Prose versus point form[edit]

"A person is more likely to develop hypothyroidism if they:

A couple of issues.

1) We should generally write in prose 2) Much of this was already covered.

So moving this here.

Doc James (talk · contribs · email) 20:19, 10 December 2017 (UTC)

  1. ^ J.Haddow, August 1999, "Hypothyroidism During Pregnancy Linked to Lower IQ for Child Early Diagnosis & Treatment May Help",New England Journal of Medicine, Iss. 19,
  2. ^ Schoenmakers, N., de Graaff, W. E., & Peters, R. H. J. (2008). "Hypothyroidism as the cause of atrioventricular block in an elderly patient". Netherlands Heart Journal16(2), 57–59.
  3. ^ Wass, John A.H., Stewart, Paul M., Amiel, Stephanie A., Davies, Melanie J. (28 July 2011). Oxford Textbook of Endocrinology and Diabetes (2nd edition). OUP Oxford.
  4. ^ Shlomo Melmed MBChB MACP (Author), Kenneth S. Polonsky MD (Author), P. Reed Larsen MD FRCP (Author), Henry M. Kronenberg MD (Author) (9 Jul 2011). Williams Textbook of Endocrinology: Expert Consult-Online and Print, 12e. Willaims.
  5. ^ "Hypothyroidism (Underactive Thyroid) | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Retrieved 2017-12-09. This article incorporates text from this source, which is in the public domain.